PMID- 21472047
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220629
IS  - 1552-5767 (Print)
IS  - 1552-5775 (Electronic)
IS  - 1552-5767 (Linking)
VI  - 11
IP  - 1
DP  - 2007 Winter
TI  - Rapid intraoperative parathyroid hormone assay in the surgical management of 
      hyperparathyroidism.
PG  - 3-6
AB  - CONTEXT: Historically, successful surgical management of primary 
      hyperparathyroidism has required bilateral exploration of the neck. By confirming 
      complete removal of hypersecreting tissue, an intraoperative parathyroid hormone 
      (IO-PTH) assay allows use of a more limited procedure. OBJECTIVE: Our objective 
      was to evaluate the utility of IO-PTH assay used in 32 parathyroid explorations 
      versus conventional bilateral exploration used before the advent of IO-PTH 
      assays. METHODS: Minimally invasive parathyroidectomy (MIP) was used. Plasma 
      samples were obtained at several intervals and were analyzed for IO-PTH by use of 
      a rapid immunochemiluminescent assay (ICMA). Outcomes were assessed by univariate 
      inferential testing, yielding one-tailed t-test results. RESULTS: The study group 
      had a mean plasma IO-PTH level decrease of 87% at ten minutes after excision. All 
      32 patients who underwent MIP using IO-PTH monitoring had successful surgery. At 
      last postoperative follow-up examination, all 32 patients were normocalcemic. 
      There were statistically significant decreases in duration of surgery, length of 
      hospital stay, and surgery cost. CONCLUSIONS: IO-PTH levels predicted the 
      postoperative outcome for all patients studied, can provide valuable information 
      to surgeons, and can decrease the duration of surgery and hospital stay.
FAU - Nelson, Craig M
AU  - Nelson CM
FAU - Victor, Noel S
AU  - Victor NS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perm J
JT  - The Permanente journal
JID - 9800474
PMC - PMC3061375
EDAT- 2007/01/01 00:00
MHDA- 2007/01/01 00:01
PMCR- 2007/12/01
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2007/01/01 00:00 [pubmed]
PHST- 2007/01/01 00:01 [medline]
PHST- 2007/12/01 00:00 [pmc-release]
AID - 10.7812/TPP/04-082 [doi]
PST - ppublish
SO  - Perm J. 2007 Winter;11(1):3-6. doi: 10.7812/TPP/04-082.