PMID- 21472067
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0973-6042 (Electronic)
IS  - 0973-6042 (Linking)
VI  - 4
IP  - 3
DP  - 2010 Jul
TI  - Cytogenetic analysis of the pathology of frozen shoulder.
PG  - 75-8
LID - 10.4103/0973-6042.76966 [doi]
AB  - BACKGROUND: Frozen shoulder (FS) is a debilitating musculoskeletal condition with 
      an uncertain etiology and pathogenic mechanism. The aim of this study was to 
      investigate the hypothesis that an alteration in the level of cytokines may 
      disrupt the normal inflammatory and tissue healing process in the shoulder, 
      leading to the development of FS. MATERIALS AND METHODS: A prospective 
      case-control study was undertaken, analyzing patients undergoing arthroscopic 
      treatment of FS and control patients being treated for subacromial bursitis. 
      Synovial biopsies were taken from all subjects. Synovial RNA levels were analyzed 
      using quantitative polymerase chain reaction (qPCR) RESULTS: Thirteen patients 
      with FS were recruited, four of whom were diagnosed with diabetes mellitus, along 
      with 10 control patients. Cytogenetic analysis using qPCR revealed both 
      fibrogenic cytokine matrix metalloproteinase 3 (MMP 3) (1.98x10 (5) vs. 755.0, 
      P=0.068) and inflammatory cytokine interleukin 6 (IL 6) (1679.2 vs. 372.8, 
      P=0.062) to be elevated in FS cases as compared to controls. Comparison between 
      diabetic and non-diabetic patients revealed a decrease in the level of expression 
      of inflammatory cytokine, monocyte colony stimulating factor (M-CSF) (12,496 vs. 
      305.1, P=0.04) in diabetic FS patients. CONCLUSIONS: The results demonstrate that 
      levels of inflammatory and fibrogenic cytokines are elevated in the synovium of 
      patients with FS compared with controls. This indicates that altered levels of 
      inflammatory cytokines may be associated with the pathogenesis of inflammation 
      evolving into fibrosis, which is the characteristic feature of FS. We have also 
      shown the opposite to be the case in patients with diabetic FS.
FAU - Kabbabe, Benjamin
AU  - Kabbabe B
AD  - The University of Melbourne, Parkville, Australia.
FAU - Ramkumar, Satish
AU  - Ramkumar S
FAU - Richardson, Martin
AU  - Richardson M
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Int J Shoulder Surg
JT  - International journal of shoulder surgery
JID - 101291740
PMC - PMC3063346
OTO - NOTNLM
OT  - Cytokines
OT  - diabetes mellitus
OT  - frozen shoulder
OT  - inflammation
OT  - matrix metalloproteinase
COIS- Conflict of Interest: None declared.
EDAT- 2011/04/08 06:00
MHDA- 2011/04/08 06:01
PMCR- 2010/07/01
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/04/08 06:01 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - IJSS-4-75 [pii]
AID - 10.4103/0973-6042.76966 [doi]
PST - ppublish
SO  - Int J Shoulder Surg. 2010 Jul;4(3):75-8. doi: 10.4103/0973-6042.76966.