PMID- 21472294
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20130222
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 3
IP  - 4
DP  - 2010 Jul-Aug
TI  - Phosphorylation of vasodilator stimulated phosphoprotein is correlated with cell 
      cycle progression in HeLa cells.
PG  - 657-62
LID - 10.3892/mmr_00000312 [doi]
AB  - Vasodilator stimulated phosphoprotein (VASP) is known as an actin-binding 
      protein. The phosphorylation of VASP plays an important role in its function. In 
      a previous study, serine 157 phosphorylated VASP (p-VASP S157) was shown to be 
      co-localized with alpha-tubulin on the spindle of SGC-7901 cells. In the present 
      study, we demonstrated that the level of p-VASP S157 increases and has a peak 
      which coincides with serine 10 phosphorylated histone 3 (p-H3 S10) during mitotic 
      progression in a human cervical cancer cell line (HeLa cells). Application of 
      protein kinase A inhibitor H89, protein kinase G inhibitor KT5823 and protein 
      kinase C inhibitor Go6983, or a combination of these inhibitors, caused a partial 
      decrease in p-VASP S157 and a delay in G2/M progression. Depletion of p-VASP S157 
      by VASP siRNA resulted in an increase in binucleated cells and x4n cells, a 
      further delay in G2/M progression and the inhibition of HeLa cell proliferation. 
      These results suggest that p-VASP S157 may play an important role in the G2/M 
      transition and the completion of cytokinesis in HeLa cells.
FAU - Tao, Yan
AU  - Tao Y
AD  - School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu 
      212013, P.R. China.
FAU - Chen, Yong-Chang
AU  - Chen YC
FAU - Sang, Jian-Rong
AU  - Sang JR
FAU - Xu, Wen-Rong
AU  - Xu WR
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
EDAT- 2011/04/08 06:00
MHDA- 2011/04/08 06:01
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/04/08 06:01 [medline]
AID - 10.3892/mmr_00000312 [doi]
PST - ppublish
SO  - Mol Med Rep. 2010 Jul-Aug;3(4):657-62. doi: 10.3892/mmr_00000312.