PMID- 21473518
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20110408
IS  - 0038-3317 (Print)
IS  - 0038-3317 (Linking)
VI  - 64
IP  - 3
DP  - 2011 Mar
TI  - Transfusion-related acute lung injury (TRALI): a case report and literature 
      review.
PG  - 85-8
AB  - Transfusion-related acute lung injury (TRALI), a previously ill-defined 
      transfusion reaction, has emerged as the leading cause of transfusion-related 
      morbidity and mortality reported to the Food and Drug Administration (FDA). A 
      3-year-old male with a history of acute lymphoblastic leukemia (ALL) developed 
      TRALI after receiving three units of platelets and a partial unit of packed red 
      cells. He recovered after 24 hours in the pediatric intensive care unit. 
      Laboratory investigation revealed that two of the four blood donors, from which 
      the platelets and packed red cells had derived, had positive human leukocyte 
      antigen (HLA) antibody screens. Further testing of these two donors revealed that 
      one had a specific HLA antibody matching an antigen of the patient. This donor 
      was implicated in the TRALI reaction. TRALI is often mistaken for other 
      transfusion reactions, most notably pulmonary edema caused by circulatory 
      overload or congestive heart failure. It is difficult to gauge which transfusion 
      recipients are at risk for TRALI. Good judgment and transfusion practices when 
      ordering blood products and recognition of the clinical manifestations, diagnosis 
      and treatment of TRALI is critical.
FAU - Donelan, Kent J
AU  - Donelan KJ
AD  - Sanford School of Medicine, University of South Dakota, USA.
FAU - Anderson, Keith A
AU  - Anderson KA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - S D Med
JT  - South Dakota medicine : the journal of the South Dakota State Medical Association
JID - 101265265
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Lung Injury/diagnosis/*etiology/prevention & control
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - Erythrocyte Transfusion/*adverse effects
MH  - HLA Antigens/*adverse effects
MH  - Humans
MH  - Male
MH  - Platelet Transfusion/*adverse effects
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy
EDAT- 2011/04/09 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PST - ppublish
SO  - S D Med. 2011 Mar;64(3):85-8.