PMID- 21473769
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20231105
IS  - 1475-2867 (Electronic)
IS  - 1475-2867 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Apr 7
TI  - Levels of certain tumor markers as differential factors between bilharzial and 
      non-biharzial bladder cancer among Egyptian patients.
PG  - 8
LID - 10.1186/1475-2867-11-8 [doi]
AB  - BACKGROUND/OBJECTIVE: Bladder cancer is the commonest type of malignant tumors as 
      a result of schistosomaisis which is a major healthy problem in many subtropical 
      developing countries. The aim of this study is to comparatively elucidate the 
      underlying biochemical tumor markers in schistosomal bladder cancer versus 
      non-schistosomal bladder cancer when compared to normal healthy ones. METHODS: 
      This work was performed on tissue specimens from total 25 patients and serum 
      samples from total 30 patients versus ten healthy individuals served as control. 
      The investigated parameters in serum are: xanthine oxidase (XO), fructosamine, 
      lactate dehydrogense (LDH), aspartate aminotransferase (AST), alanine 
      aminotransferase (ALT), total proteins, essential and non- essential amino acids 
      profile, hydroxyproline, total immunoglobulin E (IgE) and tumor necrosis factor 
      alpha (TNF-alpha). In addition, the current investigation also extended to study some 
      markers in tumor bladder tissues including, pyruvate kinase enzyme (PK), lactate 
      dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine 
      aminotransferase (ALT). RESULTS: Results showed that biharzial bladder cancer 
      patients recored more significant elevation in serum XO, fructosamine, LDH, AST, 
      ALT, hydroxyproline, IgE and TNF-alpha than in bladder cancer patients when compared 
      to control ones. While, in tissues there were significant increase in PK, LDH, 
      AST & ALT activities of schistosomal bladder cancer than in bladder cancer as 
      compared to control healthy patients. CONCLUSIONS: It could be concluded that, 
      bilharzial and non-bilharzial bladder cancer showed distinct biochemical profile 
      of tumor development and progression which can be taken into consideration in 
      diagnosis of bladder cancer.
FAU - Metwally, Nadia S
AU  - Metwally NS
AD  - Theraputic Chemistry Department, National Research Center, Dokki, Egypt. 
      nadiametwally@yahoo.com.
FAU - Ali, Sanaa A
AU  - Ali SA
FAU - Mohamed, Azza M
AU  - Mohamed AM
FAU - Khaled, Hussein M
AU  - Khaled HM
FAU - Ahmed, Samia A
AU  - Ahmed SA
LA  - eng
PT  - Journal Article
DEP - 20110407
PL  - England
TA  - Cancer Cell Int
JT  - Cancer cell international
JID - 101139795
PMC - PMC3097143
EDAT- 2011/04/09 06:00
MHDA- 2011/04/09 06:01
CRDT- 2011/04/09 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/04/07 00:00 [accepted]
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/04/09 06:01 [medline]
AID - 1475-2867-11-8 [pii]
AID - 10.1186/1475-2867-11-8 [doi]
PST - epublish
SO  - Cancer Cell Int. 2011 Apr 7;11(1):8. doi: 10.1186/1475-2867-11-8.