PMID- 21473827
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20161125
IS  - 1003-0603 (Print)
IS  - 1003-0603 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Apr
TI  - [Study of the effects of mechanical ventilation on the heart function of patients 
      with echocardiography].
PG  - 232-5
AB  - OBJECTIVE: To study the effects of different positive end expiratory pressure 
      (PEEP) levels on the heart function of patients undergoing mechanical ventilation 
      (MV) with echocardiography. METHODS: Thirty six critical patients with 
      respiratory failure undergoing MV were divided into two groups according to the 
      cardiac index (CI). The left heart function was measured with echocardiography at 
      different PEEP levels (0, 4, 7, 10, 14 cm H(2)O, 1 cm H(2)O=0.098 kPa). RESULTS: 
      In the normal cardiac function group (CI>/=2.0 Lxmin(-1) xm(-2) , n=17), an 
      increase in PEEP had no significant effects on left ventricular systolic function 
      [left ventricular end systolic volume (LVESV), left ventricular end diastolic 
      volume (LVEDV), cardiac output (CO), ejection fraction (EF)]. The increase in 
      PEEP had no significant effect on left ventricular diastolic function [mitral 
      early diastolic filling velocity (E), late diastolic filling velocity (A), the 
      ratio of E/A, early diastolic velocity (Ve), late diastolic velocity (Va), the 
      ratio of Ve/Va, left ventricular end diastolic pressure (LVEDP)]. In the poor 
      cardiac function group (CIP<2.0 Lxmin(-1) xm(-2), n=19), when PEEP was increased 
      to 10 cm H(2)O and 14 cm H(2)O, compared with PEEP 0, left ventricular systolic 
      function indexes including LVESV (ml: 21.2+/-1.2 vs. 18.2+/-1.4 as 10 cm H(2)O) was 
      significantly higher, i.e. LVEDV (ml: 42.6+/-2.4, 40.1+/-1.9 vs. 44.5+/-3.5), CO (L: 
      2.3+/-0.6, 2.1+/-0.7 vs. 2.6+/-0.7), EF (0.40+/-0.02, 0.39+/-0.02 vs. 0.42+/-0.02) were 
      decreased (all P<0.05); left ventricular diastolic function indexes including A 
      (cm/s: 88.5+/-15.2, 93.2+/-18.7 vs. 76.0+/-9.0), Va (cm/s: 14.3+/-4.5, 15.8+/-5.3 vs. 
      12.0+/-1.2), LVEDP [mm Hg (1 mm Hg=0.133 kPa): 15.3+/-2.0, 16.9+/-2.8 vs. 10.7+/-2.5] 
      were significantly higher; E (cm/s: 73.6+/-15.4, 63.2+/-16.4 vs. 83.1+/-20.1), the 
      ratio of E/A (0.83+/-0.10, 0.68+/-0.20 vs. 1.10+/-0.20), Ve (cm/s: 11.7+/-1.8, 10.4+/-2.0 
      vs. 13.8+/-2.8), the ratio of Ve/Va (0.8+/-0.1 , 0.6+/-0.2 vs. 1.2+/-0.2) were decreased 
      (all P<0.05). CONCLUSION: Under the same condition of MV, change in PEEP levels 
      (0-14 cm H(2)O) do not produce any obvious effect in the normal cardiac function 
      group, on the other hand when PEEP>/=10 cm H(2)O left heart function is 
      significantly lowered in the poor cardiac function group. Optimal PEEP may 
      improve the cardiac function.
FAU - Bai, Jing-Hui
AU  - Bai JH
AD  - Intensive Care Unit, Liaoning Cancer Hospital, Shenyang 110042, Liaoning, China. 
      baijinghui559@163.com
FAU - Chou, Wei-Ping
AU  - Chou WP
FAU - Zang, Bin
AU  - Zang B
LA  - chi
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - China
TA  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo 
      weizhongbing jijiuyixue
JID - 9887521
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Output
MH  - *Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Positive-Pressure Respiration/*methods
MH  - Respiratory Insufficiency/*diagnostic imaging/*physiopathology/therapy
EDAT- 2011/04/09 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Apr;23(4):232-5.