PMID- 21475858
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20130222
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 2
IP  - 3
DP  - 2009 May-Jun
TI  - Hesperetin inhibits the maturation and function of monocyte-derived dendritic 
      cells from patients with asthma.
PG  - 509-13
LID - 10.3892/mmr_00000129 [doi]
AB  - Dendritic cells (DCs) are crucial regulators of allergic diseases. Hesperetin, an 
      important bioactive compound in Chinese traditional medicine, has antioxidant and 
      anti-allergic properties. In this study, we examined whether hesperetin 
      influences surface molecule expression, cytokine production, the capacity to 
      induce T cell proliferation, and the underlying signaling pathway in 
      monocyte-derived DCs from patients with allergic asthma. The results show that 
      hesperetin significantly suppressed Der p 1-induced HLA-DR, CD86 and CD83 
      expression in DCs. However, the secretion of IL-10 was not affected. 
      Hesperetin-treated DCs exhibited a reduced ability to stimulate autologous CD4+ T 
      cells, accompanied by less Th2 polarization. In addition, the Der p 1-induced 
      phosphorylation of IkappaBalpha and the translocation of NF-kappaB p65 were inhibited in the 
      presence of hesperetin. These novel findings provide insight into the 
      immunopharmacological role of hesperetin in DC-based allergic diseases.
FAU - Gu, Xiaouan
AU  - Gu X
AD  - Department of Respiratory Medicine, The 454th Hospital of Chinese PLA, Nanjing 
      210002, P.R. China.
FAU - Zhou, Linfu
AU  - Zhou L
FAU - Du, Qiang
AU  - Du Q
FAU - Jiang, Desheng
AU  - Jiang D
FAU - Yang, Xiaofan
AU  - Yang X
FAU - Ji, Xiaohui
AU  - Ji X
FAU - Yin, Kaisheng
AU  - Yin K
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
EDAT- 2009/05/01 00:00
MHDA- 2009/05/01 00:01
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2009/05/01 00:00 [pubmed]
PHST- 2009/05/01 00:01 [medline]
AID - 10.3892/mmr_00000129 [doi]
PST - ppublish
SO  - Mol Med Rep. 2009 May-Jun;2(3):509-13. doi: 10.3892/mmr_00000129.