PMID- 21475918
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20240109
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 2
IP  - 6
DP  - 2009 Nov-Dec
TI  - Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity 
      conditions in a murine model.
PG  - 897-902
LID - 10.3892/mmr_00000189 [doi]
AB  - Fucoxanthin, a characteristic carotenoid of brown algae, has been reported to 
      exert an anti-diabetic effect in an obese murine model. Wakame (Undaria 
      pinnatifida), an edible seaweed, is rich in fucoxanthin. This study examined the 
      anti-obesity and anti-diabetic effects of fucoxanthin-rich wakame lipids (WLs) on 
      high fat (HF) diet-induced obesity in mice. Mice were fed a high fat control 
      (HFC) or normal fat control (NFC) diet for 10 weeks. The HF diet-fed group was 
      administered a HF diet containing WLs for a further 5 weeks. Parameters related 
      to diabetes and obesity conditions were evaluated and compared. The HF-WL diet, 
      which was rich in fucoxanthin, significantly suppressed body weight and white 
      adipose tissue (WAT) weight gain induced by the HF diet. Dietary administration 
      of the HF diet resulted in hyperglycemia, hyperinsulinemia and hyperleptinemia in 
      the mouse model. These perturbations were completely normalized in the HF-WL 
      diet-fed group. Increased expression of monocyte chemoattractant protein-1 
      (MCP-1) mRNA expression was observed in HFC mice, but was normalized in the HF-WL 
      groups. Moreover, the HF-WL diet promoted mRNA expression of beta3-adrenergic 
      receptor (Adrb3) in WAT and glucose transporter 4 (GLUT4) mRNA in skeletal muscle 
      tissues. These results suggest that dietary WLs may ameliorate alterations in 
      lipid metabolism and insulin resistance induced by a HF diet. There is therefore 
      a biochemical and nutritional basis for the application of fucoxanthin-rich WLs 
      as a functional food to prevent obesity and diabetes-related disorders.
FAU - Maeda, Hayato
AU  - Maeda H
AD  - Faculty of Agriculture and Life Science, Hirosaki University, Aomori 036-8561, 
      Japan. hayatosp@cc.hirosaki-u.ac.jp.
FAU - Hosokawa, Masashi
AU  - Hosokawa M
FAU - Sashima, Tokutake
AU  - Sashima T
FAU - Murakami-Funayama, Katsura
AU  - Murakami-Funayama K
FAU - Miyashita, Kazuo
AU  - Miyashita K
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
EDAT- 2009/11/01 00:00
MHDA- 2009/11/01 00:01
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2009/11/01 00:00 [pubmed]
PHST- 2009/11/01 00:01 [medline]
AID - 10.3892/mmr_00000189 [doi]
PST - ppublish
SO  - Mol Med Rep. 2009 Nov-Dec;2(6):897-902. doi: 10.3892/mmr_00000189.