PMID- 21476000
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20221207
IS  - 1573-7217 (Electronic)
IS  - 0167-6806 (Linking)
VI  - 129
IP  - 2
DP  - 2011 Sep
TI  - TNF-alpha polymorphisms and breast cancer.
PG  - 513-9
LID - 10.1007/s10549-011-1494-2 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an important pro-inflammatory cytokine in the 
      development and progress in human cancer. TNF-alpha polymorphisms have been confirmed 
      to influence the risk for several types of cancer, however, the associations 
      between TNF-alpha polymorphisms and breast cancer (BC) remain controversial and 
      ambiguous. The aim of this meta-analysis is to explore more precise estimations 
      regarding this point. Electronic searches of several databases were conducted for 
      all online publications on the associations between TNF-alpha-238, -308, -857, -863, 
      -1031, -1210 polymorphisms and BC through March 2011. Odds ratios (OR) with 95% 
      confidence intervals (95% CI) were calculated to assess the strength of these 
      associations in fixed- and random-effect models with Review manager 5.0. A total 
      of 17 studies with 44,442 BC patients and 49,926 controls involved were 
      identified. This meta-analysis showed no significant association between 
      TNF-alpha-308 polymorphism and BC (AA + GA vs. GG: OR = 0.95, 95% CI = 0.82-1.09) in 
      overall and (OR = 1.44, 95% CI = 0.61-3.40) Asian populations, however, a 
      negative association was shown in Caucasian subgroup (OR = 0.91, 95% 
      CI = 0.85-0.97). As regards the TNF-alpha-238 polymorphism, the OR values (95% CI) 
      were 0.99 (0.94-1.05), 0.94 (0.78-1.14), and 1.00 (0.95-1.05) for the overall, 
      Asian, and Caucasian studies, respectively. No significant associations were 
      found for other polymorphisms. Furthermore, there was a coincidence in the 
      sensitivity analysis of these associations. No publication bias was detected in 
      this study. To sum up, no significant associations were found between the 
      TNF-alpha-308, -238, -857, -863, -1031, -1210 polymorphisms and the risk for BC in 
      overall populations, whereas a negative association was found between TNF-alpha-308 
      polymorphism and BC in Caucasian populations.
FAU - Yang, Yu
AU  - Yang Y
AD  - Department of Oncology, The Second Affiliated Hospital of Harbin Medical 
      University, 246 Xuefu Road, 150086, Harbin, People's Republic of China.
FAU - Feng, Rennan
AU  - Feng R
FAU - Bi, Sheng
AU  - Bi S
FAU - Xu, Yuqing
AU  - Xu Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110408
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CIN - Breast Cancer Res Treat. 2011 Oct;129(3):1011-3. PMID: 21559823
CIN - Breast Cancer Res Treat. 2011 Oct;129(3):1015-7. PMID: 21597918
MH  - Asian People/genetics
MH  - Breast Neoplasms/ethnology/*genetics/immunology
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - White People/genetics
EDAT- 2011/04/09 06:00
MHDA- 2012/09/15 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/03/13 00:00 [received]
PHST- 2011/03/28 00:00 [accepted]
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - 10.1007/s10549-011-1494-2 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 2011 Sep;129(2):513-9. doi: 10.1007/s10549-011-1494-2. 
      Epub 2011 Apr 8.