PMID- 21476209
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20131121
IS  - 1793-6853 (Electronic)
IS  - 0192-415X (Linking)
VI  - 39
IP  - 2
DP  - 2011
TI  - Injectable caltrop fruit saponin protects against ischemia-reperfusion injury in 
      rat brain.
PG  - 325-33
AB  - The present study aimed to investigate the protective effects of injectable 
      caltrop fruit saponin preparation (ICFSP) on ischemia-reperfusion injury in rat 
      brain. Rats were injected with ICFSP and then subjected to cerebral 
      ischemia-reperfusion injury induced by middle cerebral artery occlusion. Then the 
      neurological deficit score was evaluated by Bederson's method. The infarct size 
      was assessed by TTC staining. The content of malondialdehyde (MDA) and nitric 
      oxide (NO), and the activity of superoxide dismutase (SOD) in rat cerebrum were 
      measured with kits, and the content of 6 K prostaglandin F1alpha (6-K-PGF 1alpha), 
      thromboxane B2 (TXB2) and endothelin (ET) in blood plasma was measured by 
      radioimmunoassay. The results demonstrated that ICFSP led to a decrease in 
      infarct size (p < 0.01), neurological deficit score (p < 0.05) and plasma content 
      of TXB2 and ET (p < 0.05), and an increase of the plasma level of 6-K-PGF 1alpha (p < 
      0.05) and SOD activity in cerebrum, where the MDA and NO content were decreased. 
      The treatment improved forelimb function. ICFSP showed a similar potency compared 
      to that of Ligustrazine hydrochloride parenteral solution (LHPS) and nimodipine 
      (Nim). We concluded that ICFSP protects the brain damage caused by 
      ischemia-reperfusion injury in rats, and this may be closely related to the 
      regulation of reactive oxygen species (MDA and SOD activity) and NO levels in the 
      rat cerebrum, as well as vasoactive factors in the plasma (6-K-PGF 1alpha, TXB2 and 
      ET).
FAU - Yan, Ling-Geng
AU  - Yan LG
AD  - College of Pharmacy, Nanjing University of Chinese Medicine, 282 Hanzhong Road, 
      Nanjing, Jiangsu, China.
FAU - Lu, Yin
AU  - Lu Y
FAU - Zheng, Shi-Zhong
AU  - Zheng SZ
FAU - Wang, Ai-Yun
AU  - Wang AY
FAU - Li, Meng-Qiu
AU  - Li MQ
FAU - Ruan, Jun-Shan
AU  - Ruan JS
FAU - Zhang, Lei
AU  - Zhang L
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Endothelins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - 0 (Saponins)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 54397-85-2 (Thromboxane B2)
RN  - 58962-34-8 (6-Ketoprostaglandin F1 alpha)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - 6-Ketoprostaglandin F1 alpha/blood
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Calcium Channel Blockers/pharmacology/therapeutic use
MH  - Cerebral Infarction/etiology/metabolism/*prevention & control
MH  - Cerebrum/*drug effects/metabolism/pathology
MH  - Endothelins/blood
MH  - Forelimb/drug effects/physiology
MH  - Fruit
MH  - Infarction, Middle Cerebral Artery
MH  - Injections
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Neuroprotective Agents/pharmacology/*therapeutic use
MH  - Nitric Oxide/metabolism
MH  - *Phytotherapy
MH  - Plant Extracts/chemistry/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/etiology/metabolism/*prevention & control
MH  - Saponins/pharmacology/*therapeutic use
MH  - Superoxide Dismutase/metabolism
MH  - *Thromboxane B2/blood
MH  - Tribulus/*chemistry
EDAT- 2011/04/09 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S0192415X11008853 [pii]
AID - 10.1142/S0192415X11008853 [doi]
PST - ppublish
SO  - Am J Chin Med. 2011;39(2):325-33. doi: 10.1142/S0192415X11008853.