PMID- 21477986
OWN - NLM
STAT- MEDLINE
DCOM- 20120824
LR  - 20181201
IS  - 1873-4588 (Electronic)
IS  - 0892-1997 (Linking)
VI  - 26
IP  - 3
DP  - 2012 May
TI  - Reflux symptom index and reflux finding score in otolaryngologic practice.
PG  - e123-7
LID - 10.1016/j.jvoice.2011.02.004 [doi]
AB  - OBJECTIVES: To evaluate whether patients with abnormal Reflux Symptom Index (RSI) 
      and Reflux Finding Score (RFS) benefit from proton pump inhibitor (PPI) therapy. 
      STUDY DESIGN: Open, multicenter, prospective longitudinal cohort study. METHODS: 
      Patients with suspected reflux-associated laryngologic symptoms were evaluated by 
      40 community practice otolaryngologists using RSI and RFS. Patients were treated 
      with pantoprazole 40-80 mg/d for 8-12 weeks if RSI was greater than 9 and RFS 
      greater than 7. Pre- and posttherapeutic RSI and RFS were compared using Wilcoxon 
      signed rank test and additionally controlled with the symmetry test of Bowker. 
      RESULTS: A total of 1044 patients were included over a period of 20 months. 
      Median total score of RSI before therapy was 12 and decreased to 3 (P<<0.001). 
      Median total score of RFS before therapy was 16 and decreased to 6 (P<<0.001). 
      Assessment of the treatment effect by otolaryngologists and patients was judged 
      as being excellent in at least 50%. In 2% of the patients, gastrointestinal side 
      effects were documented. CONCLUSION: RSI and RSF are easy to administer in the 
      routine care of patients suspected of having laryngopharyngeal reflux. Patients 
      identified by positive results of these tests have a high likelihood of excellent 
      improvement after 8-12 weeks of PPI treatment. By implementation of RFS and RSI 
      in daily use, most patients may not need time-consuming and cost-intensive 
      examinations in the first-line assessment of LPR. These examinations can be 
      reserved for nonresponders, and uncontrolled prescription of PPIs can be 
      restricted.
CI  - Copyright (c) 2012 The Voice Foundation. Published by Mosby, Inc. All rights 
      reserved.
FAU - Habermann, Walter
AU  - Habermann W
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Medical University of 
      Graz, Graz, Austria. w_habermann@yahoo.com
FAU - Schmid, Christoph
AU  - Schmid C
FAU - Neumann, Kurt
AU  - Neumann K
FAU - Devaney, Trevor
AU  - Devaney T
FAU - Hammer, Heinz F
AU  - Hammer HF
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110407
PL  - United States
TA  - J Voice
JT  - Journal of voice : official journal of the Voice Foundation
JID - 8712262
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - D8TST4O562 (Pantoprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Austria
MH  - Female
MH  - Humans
MH  - Laryngopharyngeal Reflux/complications/*diagnosis/drug therapy
MH  - *Laryngoscopy
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Pantoprazole
MH  - Patient Selection
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Referral and Consultation
MH  - Severity of Illness Index
MH  - *Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/04/12 06:00
MHDA- 2012/08/25 06:00
CRDT- 2011/04/12 06:00
PHST- 2010/11/28 00:00 [received]
PHST- 2011/02/14 00:00 [accepted]
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2012/08/25 06:00 [medline]
AID - S0892-1997(11)00032-4 [pii]
AID - 10.1016/j.jvoice.2011.02.004 [doi]
PST - ppublish
SO  - J Voice. 2012 May;26(3):e123-7. doi: 10.1016/j.jvoice.2011.02.004. Epub 2011 Apr 
      7.