PMID- 21479602
OWN - NLM
STAT- MEDLINE
DCOM- 20121121
LR  - 20211020
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 32
IP  - 7
DP  - 2012 Jul
TI  - Prevalence of hepatitis B surface antigen in patients with ankylosing spondylitis 
      and its association with HLA-B27: a retrospective study from south China.
PG  - 2011-6
LID - 10.1007/s00296-011-1934-7 [doi]
AB  - To investigate the prevalence of hepatitis B surface antigen (HBsAg), a 
      seromarker for current infection of hepatitis B virus, in patients with 
      ankylosing spondylitis (AS) from south China and to evaluate its association with 
      human leukocyte antigen (HLA)-B27. The prevalence of HBsAg was retrospectively 
      investigated in 439 patients with AS, 606 age- and sex-matched general 
      individuals, 172 patients with other spondyloarthropathy (SpA), 698 patients with 
      rheumatoid arthritis (RA), and 220 patients with osteoarthritis (OA). The 
      positive rate of HBsAg in AS group was compared with those of the general 
      population group and other disease groups, respectively, and the prevalence of 
      HBsAg was compared between HLA-B27-positive and HLA-B27-negative patients with 
      AS. The positive rate of HBsAg in AS patients, general population, other-SpA, RA, 
      and OA patients were 25.39, 12.87, 14.53, 9.60, and 8.18%, respectively. The 
      HBsAg prevalence of AS group was statistically higher than those of any other 
      groups (P < 0.05). The prevalence of HBsAg in HLA-B27-positive and 
      HLA-B27-negative AS patients were 26.68 and 14.49%, respectively, the positive 
      rate of HBsAg in HLA-B27-positive AS patients was statistically higher than that 
      of HLA-B27-negative AS patients (P < 0.05). The prevalence of HBsAg in AS 
      patients was higher than those in general population, patients with other-SpA, 
      RA, and OA. The high HBsAg prevalence in AS patients might be associated with 
      their high frequency of HLA-B27 gene.
FAU - Zheng, Benrong
AU  - Zheng B
AD  - Department of VIP health care Center, Third Affiliated Hospital of Sun Yat-Sen 
      University, 600 Tianhe Road, Guangzhou 510630, China.
FAU - Li, Tianwang
AU  - Li T
FAU - Lin, Qu
AU  - Lin Q
FAU - Huang, Zhixiang
AU  - Huang Z
FAU - Wang, Min
AU  - Wang M
FAU - Deng, Weiming
AU  - Deng W
FAU - Liao, Zetao
AU  - Liao Z
FAU - Gu, Jieruo
AU  - Gu J
LA  - eng
PT  - Journal Article
DEP - 20110409
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Hepatitis B Surface Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arthritis, Rheumatoid/epidemiology/immunology
MH  - China/epidemiology
MH  - Female
MH  - HLA-B27 Antigen/*immunology
MH  - Hepatitis B Surface Antigens/analysis/*immunology
MH  - Humans
MH  - Male
MH  - Osteoarthritis/epidemiology/immunology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Spondylitis, Ankylosing/*epidemiology/*immunology
MH  - Young Adult
EDAT- 2011/04/12 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/04/12 06:00
PHST- 2010/12/28 00:00 [received]
PHST- 2011/03/27 00:00 [accepted]
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1007/s00296-011-1934-7 [doi]
PST - ppublish
SO  - Rheumatol Int. 2012 Jul;32(7):2011-6. doi: 10.1007/s00296-011-1934-7. Epub 2011 
      Apr 9.