PMID- 21479986
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20211020
IS  - 1437-7799 (Electronic)
IS  - 1342-1751 (Linking)
VI  - 15
IP  - 4
DP  - 2011 Aug
TI  - Obesity and chronic kidney disease in patients with chronic heart failure: an 
      insight from the China Heart Survey.
PG  - 522-8
LID - 10.1007/s10157-011-0443-z [doi]
AB  - BACKGROUND: Obesity and decreased kidney function have been shown to be prevalent 
      in Western patients with heart failure; however, whether this phenomenon exists 
      in Chinese patients with chronic heart failure (CHF) is not known. METHODS AND 
      RESULTS: One thousand and nine patients with CHF from the China Heart Survey were 
      assessed. The prevalence of chronic kidney disease (CKD) was 34.2%, and there was 
      a stepwise increase in the prevalence of CKD with New York Heart Association 
      (NYHA) classes (P < 0.001). Moreover, patients with CKD had a significantly 
      elevated risk for developing severe extent of CHF (OR = 1.69, 95% CI: 1.27-2.24, 
      P < 0.001). The prevalence of obesity and central obesity was 35.7% and 62.5%, 
      respectively. Notably, there was a downward trend in the prevalence of obesity 
      with advanced NYHA classes (trend test, P = 0.003). Multivariate analysis further 
      supported the finding that obesity, but not central obesity, was inversely 
      associated with the extent of CHF (OR = 0.72, 95% CI: 0.55-0.94, P = 0.017). 
      CONCLUSIONS: Renal dysfunction is common in Chinese patients with CHF and is 
      independently associated with advanced NYHA classes. Obesity was inversely 
      associated with the extent of CHF, which further supports the notion that obesity 
      confers improved prognosis in patients with heart failure.
FAU - Liu, Hao
AU  - Liu H
AD  - Clinical Research Institute, School of Public Health, Fudan University, 130 
      Dong-An Rd., Shanghai 200032, China.
FAU - Shi, Hong
AU  - Shi H
FAU - Yu, Jinming
AU  - Yu J
FAU - Chen, Fang
AU  - Chen F
FAU - Jiang, Qingwu
AU  - Jiang Q
FAU - Hu, Dayi
AU  - Hu D
LA  - eng
PT  - Journal Article
DEP - 20110412
PL  - Japan
TA  - Clin Exp Nephrol
JT  - Clinical and experimental nephrology
JID - 9709923
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - China/epidemiology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Heart Failure/*complications/epidemiology
MH  - Humans
MH  - Kidney Failure, Chronic/*complications/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Obesity/*complications/epidemiology
MH  - Prevalence
MH  - Prognosis
MH  - Renal Insufficiency, Chronic/*complications/epidemiology
EDAT- 2011/04/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/12 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2011/03/23 00:00 [accepted]
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10157-011-0443-z [doi]
PST - ppublish
SO  - Clin Exp Nephrol. 2011 Aug;15(4):522-8. doi: 10.1007/s10157-011-0443-z. Epub 2011 
      Apr 12.