PMID- 21481110
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20120723
IS  - 1365-3156 (Electronic)
IS  - 1360-2276 (Linking)
VI  - 16
IP  - 8
DP  - 2011 Aug
TI  - Conserved sequences of thrombospondin-related adhesive protein gene of Plasmodium 
      vivax in clinical isolates from Korea.
PG  - 923-8
LID - 10.1111/j.1365-3156.2011.02784.x [doi]
AB  - Thrombospondin-related adhesive protein (TRAP) from Plasmodium vivax (P. vivax) 
      became one of the important vaccine candidates for malaria, because P. vivax TRAP 
      (PvTRAP) is responsible for the sporozoite-host interactions. PvTRAP 
      polymorphisms in the isolates from Republic of Korea (ROK) were analysed, setting 
      the valuable baseline data for the future vaccine developments and clinical 
      trials with PvTRAP, as a strong vaccine candidate. A total of 54 isolates were 
      collected in 2010. PvTRAP genes from above isolates were amplified and sequenced, 
      and the results were analysed and compared against Sal-1 strain. Sequencing 
      analysis of 1424-bp-size PvTRAP PCR products revealed one major allelic type with 
      six non-synonymous substitutions, where S81T, E95D, I121V and T127R substitutions 
      were found in region II, and K371N and A425E substitutions from region IV. The 
      ROK isolates revealed the limited sequence polymorphisms in PvTRAP in comparison 
      with the reported isolates from other nations.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Nam, Myung H
AU  - Nam MH
AD  - Department of Laboratory Medicine, College of Medicine, Korea University, Seoul, 
      Korea.
FAU - Jang, Jin W
AU  - Jang JW
FAU - Kim, Hanna
AU  - Kim H
FAU - Han, Eun T
AU  - Han ET
FAU - Lee, Won J
AU  - Lee WJ
FAU - An, Seong S A
AU  - An SS
FAU - Park, Ae S D
AU  - Park AS
FAU - Lim, Chae S
AU  - Lim CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110411
PL  - England
TA  - Trop Med Int Health
JT  - Tropical medicine & international health : TM & IH
JID - 9610576
RN  - 0 (Protozoan Proteins)
RN  - 0 (Vaccines)
RN  - 120300-02-9 (thrombospondin-related adhesive protein, protozoan)
SB  - IM
MH  - Animals
MH  - Conserved Sequence/genetics
MH  - Genes, Protozoan/*genetics
MH  - Humans
MH  - Malaria, Vivax/*genetics
MH  - Plasmodium vivax/*isolation & purification
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Protozoan Proteins/*genetics
MH  - Republic of Korea
MH  - Vaccines/genetics
EDAT- 2011/04/13 06:00
MHDA- 2012/10/17 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - 10.1111/j.1365-3156.2011.02784.x [doi]
PST - ppublish
SO  - Trop Med Int Health. 2011 Aug;16(8):923-8. doi: 10.1111/j.1365-3156.2011.02784.x. 
      Epub 2011 Apr 11.