PMID- 21481411
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20110425
IS  - 1095-7103 (Electronic)
IS  - 0021-9797 (Linking)
VI  - 358
IP  - 2
DP  - 2011 Jun 15
TI  - Comparison of epithelial and fibroblastic cell behavior on nano/micro-topographic 
      PCL membranes produced by crystallinity control.
PG  - 444-53
LID - 10.1016/j.jcis.2011.03.026 [doi]
AB  - In this study, the relationship between the cellular morphology and the material 
      surface topography was investigated. Poly(epsilon-caprolactone) (PCL) membranes were 
      prepared in a wide range of surface wettabilities by means of 
      crystallinity-controlled solvent casting process. Membrane surfaces were 
      characterized by atomic force microscope (AFM), scanning electron microscope 
      (SEM), and static/dynamic water contact angle measurements. It was found that 
      solvent evaporation and non-solvent (methanol) addition to the solvent (THF) are 
      the most decisive parameters to change the surface topography. The non-solvent 
      addition and the decrease in solvent evaporation temperature from room 
      temperature to -20  degrees C caused increased polymeric chain mobility and 
      crystallization time. Such changes in crystallization parameters led to the 
      formation of micro/nano-sized features on the membrane. Cell culture studies 
      indicated that in contrast to Madin Darby kidney (MDBK) epithelial cells, L929 
      mouse fibroblast preferred rough and porous surfaces.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Gumusderelioglu, Menemse
AU  - Gumusderelioglu M
AD  - Hacettepe University, Chemical Eng. Dept., 06800 Beytepe, Ankara, Turkey. 
      menemse@hacettepe.edu.tr
FAU - Kaya, F Betul
AU  - Kaya FB
FAU - Beskardes, Isil Gercek
AU  - Beskardes IG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110312
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 0 (Polyesters)
RN  - 0 (Solvents)
RN  - 24980-41-4 (polycaprolactone)
SB  - IM
MH  - Animals
MH  - Cell Culture Techniques/methods
MH  - Cell Line
MH  - Crystallization
MH  - Dogs
MH  - Epithelial Cells/*cytology
MH  - Fibroblasts/*cytology
MH  - Mice
MH  - Nanoparticles/*chemistry
MH  - *Polyesters
MH  - Porosity
MH  - Solvents
MH  - Surface Properties
EDAT- 2011/04/13 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/03/06 00:00 [revised]
PHST- 2011/03/08 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - S0021-9797(11)00302-X [pii]
AID - 10.1016/j.jcis.2011.03.026 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2011 Jun 15;358(2):444-53. doi: 
      10.1016/j.jcis.2011.03.026. Epub 2011 Mar 12.