PMID- 21484240
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 217
IP  - 2
DP  - 2011 Sep
TI  - GABA(B) receptor blockade in the hippocampus affects sensory and sensorimotor 
      gating in Long-Evans rats.
PG  - 167-76
LID - 10.1007/s00213-011-2274-8 [doi]
AB  - RATIONALE: Sensory and sensorimotor gating deficits are observed in 
      schizophrenia. GABA(B) receptor deficiency is also detected in the hippocampus of 
      schizophrenic patients. OBJECTIVES: The present study tested the hypothesis that 
      GABA(B) receptors in the hippocampus contribute to paired-pulse gating of 
      hippocampal auditory-evoked potentials (AEP) and auditory prepulse inhibition 
      (PPI) in Long-Evans rats. METHODS: Gating of hippocampal AEP, or PPI, was 
      examined before and after administration of GABA(B) receptor antagonist, 
      CGP56999A or CGP35348, or saline was administered either systemically 
      (intra-peritoneally (i.p.)) or infused bilaterally into the hippocampus 15 min 
      before gating measurements. RESULTS: Systemic injection of CGP56999A, at a dose 
      of 0.2 and 0.4 mg/kg i.p. resulted in reduced gating of hippocampal AEP in a 
      dose-dependent manner. Reduced gating was found at conditioning-test interpulse 
      intervals of 300-500 ms, but not 100-200 ms. Reduced gating of hippocampal AEP 
      also followed bilateral infusion of CGP56999A into the hippocampus 
      (0.1 mug/muL/side). Gating loss was attributed to a decreased conditioning response 
      and an increased test response after systemic or local injection of CGP56999A. 
      Robust PPI was found at prepulse-pulse intervals of 30-100 ms, and this PPI was 
      reduced by hippocampal infusion of CGP56999A in a dose-dependent manner, as 
      compared with saline infusion. CONCLUSIONS: Blockade of hippocampal GABA(B) 
      receptors led to deficits in sensory and sensorimotor gating, which are symptoms 
      of schizophrenia.
FAU - Ma, Jingyi
AU  - Ma J
AD  - Department of Physiology and Pharmacology, Medical Sciences Building, The 
      University of Western Ontario, London, ON, Canada, N6A 5C1. jma2@uwo.ca
FAU - Leung, L Stan
AU  - Leung LS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110412
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (GABA-B Receptor Antagonists)
RN  - 0 (Receptors, GABA-B)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain Mapping
MH  - Evoked Potentials, Auditory/*drug effects
MH  - GABA-B Receptor Antagonists/*pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, GABA-B/*metabolism
MH  - Schizophrenic Psychology
MH  - Sensory Gating/*drug effects
EDAT- 2011/04/13 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/04/13 06:00
PHST- 2010/11/07 00:00 [received]
PHST- 2011/03/14 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1007/s00213-011-2274-8 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2011 Sep;217(2):167-76. doi: 
      10.1007/s00213-011-2274-8. Epub 2011 Apr 12.