PMID- 21484950
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20220317
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 32
IP  - 5
DP  - 2011 May
TI  - Pramipexole modulates the neural network of reward anticipation.
PG  - 800-11
LID - 10.1002/hbm.21067 [doi]
AB  - Pramipexole is widely prescribed to treat Parkinson's disease. It has been found 
      to cause impulse control disorders such as pathological gambling. To examine how 
      pramipexole modulates the network of reward anticipation, we carried out a 
      pharmacological functional magnetic resonance imaging study with a double-blind, 
      within-subject design. During the anticipation of monetary rewards, pramipexole 
      increased the activity of the nucleus accumbens (NAcc), enhanced the interaction 
      between the NAcc and the anterior insula, but weakened the interaction between 
      the NAcc and the prefrontal cortex. These results suggest that pramipexole may 
      exaggerate incentive and affective responses to possible rewards, but reduce the 
      top-down control of impulses, leading to an increase in impulsive behaviors. This 
      imbalance between the prefrontal-striatum connectivity and the insula-striatum 
      connectivity may represent the neural mechanism of pathological gambling caused 
      by pramipexole.
CI  - Copyright (c) 2010 Wiley-Liss, Inc.
FAU - Ye, Zheng
AU  - Ye Z
AD  - Department of Psychology, Peking University, Beijing, China.
FAU - Hammer, Anke
AU  - Hammer A
FAU - Camara, Estela
AU  - Camara E
FAU - Munte, Thomas F
AU  - Munte TF
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
RN  - 0 (Benzothiazoles)
RN  - 0 (Dopamine Agonists)
RN  - 83619PEU5T (Pramipexole)
SB  - IM
MH  - Adult
MH  - Anticipation, Psychological/*drug effects/physiology
MH  - Benzothiazoles/*pharmacology
MH  - Brain/*drug effects/physiology
MH  - *Brain Mapping
MH  - Cross-Over Studies
MH  - Dopamine Agonists/*pharmacology
MH  - Double-Blind Method
MH  - Gambling/chemically induced/physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/drug effects/physiology
MH  - Pramipexole
MH  - Reward
MH  - Young Adult
PMC - PMC6870097
EDAT- 2011/04/13 06:00
MHDA- 2011/08/04 06:00
PMCR- 2011/04/11
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PHST- 2011/04/11 00:00 [pmc-release]
AID - HBM21067 [pii]
AID - 10.1002/hbm.21067 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2011 May;32(5):800-11. doi: 10.1002/hbm.21067.