PMID- 21488218
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20220327
IS  - 1008-9292 (Print)
IS  - 1008-9292 (Linking)
VI  - 40
IP  - 2
DP  - 2011 Mar
TI  - [Expression of high mobility group box chromosomal protein 1 in mice with lupus 
      nephritis].
PG  - 200-6
AB  - OBJECTIVE: To determine the role of the novel proinflammatory cytokine high 
      mobility group box chromosomal protein 1 (HMGB-1) in the pathogenesis of lupus 
      nephritis. METHODS: Serum levels of anti-dsDNA antibodies were determined by 
      enzyme linked immunosorbent assay (ELISA). Renal morphologic features were 
      examined by light microscopy, electron microscopy, and immunohistologic analyses. 
      The mRNA expression of HMGB-1 and monocyte chemoattractant protein-1 (MCP-1) was 
      detected by RT-PCR. RESULT: MRL/lpr mice demonstrated characteristic alterations 
      of serum immune parameters, with progressively increased anti-dsDNA antibodies 
      with age, compared with age-matched C57BL/6J mice. MRL/lpr mice showed 
      progressive development of renal damage, starting at 12 weeks of age and reached 
      the peak at 20 weeks. The observed lesions included the presence of enlarged 
      hypercellular glomeruli, with increased numbers of both resident cells and 
      infiltrating leukocytes. Higher expression of HMGB-1 mRNA was found in MRL/lpr 
      mice than what in C57BL/6J mice. Expression of HMGB-1 was positively correlated 
      with that of MCP-1 mRNA. CONCLUSION: The results demonstrate that the higher 
      expression of HMGB-1 may contribute to the pathogenesis of lupus nephritis.
FAU - Zhou, Jian-Guang
AU  - Zhou JG
AD  - Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, 
      China. jianguangzhou@gmail.com
FAU - Dong, Jing-Yin
AU  - Dong JY
FAU - Zhang, Li-Huang
AU  - Zhang LH
FAU - Wang, Jing
AU  - Wang J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhejiang Da Xue Xue Bao Yi Xue Ban
JT  - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical 
      sciences
JID - 100927946
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (HMGB1 Protein)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/metabolism
MH  - Disease Models, Animal
MH  - HMGB1 Protein/genetics/*metabolism
MH  - Kidney/metabolism/pathology
MH  - Lupus Nephritis/*metabolism/pathology
MH  - Mice
MH  - Mice, Inbred MRL lpr
MH  - RNA, Messenger/genetics
EDAT- 2011/04/14 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - 10.3785/j.issn.1008-9292.2011.02.014 [doi]
PST - ppublish
SO  - Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Mar;40(2):200-6. doi: 
      10.3785/j.issn.1008-9292.2011.02.014.