PMID- 21488335 OWN - NLM STAT- MEDLINE DCOM- 20110804 LR - 20191112 IS - 0042-6857 (Print) IS - 0042-6857 (Linking) VI - 60 IP - 2 DP - 2010 Dec TI - [Human herpesvirus-6 and human herpesvirus-7 (HHV-6, HHV-7)]. PG - 221-35 AB - human herpesvirus 6 (HHV-6) is the major causative agent of exanthem subitum which is one of popular diseases in infant, and establishes latent infections in adults of more than 90%. Recently, the encephalitis caused by reactivated- HHV-6 has been shown in patients after transplantation. In addition, the relationship HHV-6 and drug-induced hypersensitivity syndrome has also been reported. human herpesvirus 7 (HHV-7) was isolated from the stimulated-peripheral blood lymphocytes of a healthy individual, and also causes exanthema subitum. Both viruses are related viruses which belong to betaherpesvirus subfamily, and replicate and produce progeny viruses in T cells. FAU - Tang, Huamin AU - Tang H AD - Division of Virology and vaccinology, National Institute of Biomedical Innovation. FAU - Sadaoka, Tomohiko AU - Sadaoka T FAU - Mori, Yasuko AU - Mori Y LA - jpn PT - Journal Article PT - Review PL - Japan TA - Uirusu JT - Uirusu JID - 0417475 RN - 0 (Membrane Cofactor Protein) RN - 0 (Receptors, Virus) SB - IM MH - Adult MH - *Exanthema Subitum/diagnosis/therapy/transmission/virology MH - Gene Expression Regulation, Viral MH - Genes, Viral/genetics MH - Genome, Viral/genetics MH - *Herpesvirus 6, Human/genetics/immunology/pathogenicity/physiology MH - *Herpesvirus 7, Human/genetics/immunology/pathogenicity/physiology MH - Humans MH - Immunity, Cellular MH - Immunity, Humoral MH - Infant MH - Membrane Cofactor Protein/physiology MH - Receptors, Virus/physiology MH - T-Lymphocytes/virology MH - Virion/pathogenicity MH - Virus Activation MH - Virus Integration MH - Virus Latency EDAT- 2011/04/15 06:00 MHDA- 2011/08/05 06:00 CRDT- 2011/04/15 06:00 PHST- 2011/04/15 06:00 [entrez] PHST- 2011/04/15 06:00 [pubmed] PHST- 2011/08/05 06:00 [medline] AID - 10.2222/jsv.60.221 [doi] PST - ppublish SO - Uirusu. 2010 Dec;60(2):221-35. doi: 10.2222/jsv.60.221.