PMID- 21489814
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20161125
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 30
IP  - 9
DP  - 2011 Sep
TI  - Antibodies against heterogeneous nuclear ribonucleoprotein K in patients with 
      cardiac allograft vasculopathy.
PG  - 1051-9
LID - 10.1016/j.healun.2011.02.014 [doi]
AB  - BACKGROUND: Cardiac allograft vasculopathy (CAV) is the most serious long-term 
      complication after cardiac transplantation. T-cell-mediated immune response has 
      been implicated as the central mechanism for this form of graft rejection, but 
      the role of humoral immunity is still controversial. METHODS: This study 
      investigated whether human leukocyte antigen (HLA) and non-HLA antibodies are 
      associated with CAV and if their presence can be used to identify patients at 
      high risk of developing CAV. Diagnosis of CAV was made by angiography and 
      intravascular ultrasound (IVUS) technology. Sera from 48 heart transplant 
      recipients were assessed for the presence of antibodies. RESULTS: Although 
      anti-HLA or anti-major histocompatibility complex class I chain-related gene A 
      (MICA) antibodies in patients with or without CAV were not statistically 
      different, heterogeneous nuclear ribonucleoprotein K (hnRNP-K) was identified as 
      a new antigenic target after the screening of a human coronary artery smooth 
      muscle cells complementary DNA (cDNA) expression library with a serum sample from 
      a CAV patient. Four years after transplantation, presence of anti-hnRNP-K 
      antibodies was significantly higher in the IVUS-defined CAV group (85.3%) and 
      angiography-defined CAV patients (90.5%) compared with the non-CAV group (p < 
      0.0001 and p = 0.0023 respectively). CONCLUSIONS: The presence of anti-hnRNP-K 
      antibodies 4 years after the transplant is statistically associated with CAV 
      disease, regardless of the diagnostic technique. Therefore, prospective detection 
      of these antibodies could be proposed as a helpful biomarker in CAV diagnosis.
CI  - Copyright (c) 2011 International Society for Heart and Lung Transplantation. 
      Published by Elsevier Inc. All rights reserved.
FAU - Acevedo, Maria J
AU  - Acevedo MJ
AD  - Immunology Service, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
FAU - Caro-Oleas, Jose L
AU  - Caro-Oleas JL
FAU - Alvarez-Marquez, Antonia J
AU  - Alvarez-Marquez AJ
FAU - Sobrino, Jose M
AU  - Sobrino JM
FAU - Lage-Galle, Ernesto
AU  - Lage-Galle E
FAU - Aguilera, Isabel
AU  - Aguilera I
FAU - Nunez-Roldan, Antonio
AU  - Nunez-Roldan A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110413
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Biomarkers)
RN  - 0 (Heterogeneous-Nuclear Ribonucleoprotein K)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/*blood
MH  - Biomarkers/blood
MH  - Coronary Angiography
MH  - Coronary Disease/complications/*epidemiology/*immunology
MH  - Coronary Vessels/diagnostic imaging
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/etiology
MH  - Heart Transplantation/*immunology
MH  - Heterogeneous-Nuclear Ribonucleoprotein K/*immunology
MH  - Histocompatibility Antigens Class I/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Transplantation, Homologous
MH  - Ultrasonography, Interventional
EDAT- 2011/04/15 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/04/15 06:00
PHST- 2010/08/24 00:00 [received]
PHST- 2010/12/14 00:00 [revised]
PHST- 2011/02/11 00:00 [accepted]
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/15 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S1053-2498(11)00790-X [pii]
AID - 10.1016/j.healun.2011.02.014 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2011 Sep;30(9):1051-9. doi: 
      10.1016/j.healun.2011.02.014. Epub 2011 Apr 13.