PMID- 21492784
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20211020
IS  - 1872-9614 (Electronic)
IS  - 0969-8051 (Print)
IS  - 0969-8051 (Linking)
VI  - 38
IP  - 3
DP  - 2011 Apr
TI  - Study of an image-derived SUV and a modified SUV using mouse FDG-PET.
PG  - 353-62
LID - 10.1016/j.nucmedbio.2010.10.002 [doi]
AB  - INTRODUCTION: Standard uptake value (SUV) is calculated without consideration of 
      the differences in plasma 2-deoxy-2-[18F]fluoro-D-glucose (FDG) clearance. Its 
      variability can be affected by changes of the amount of excreted FDG by renal 
      function. Moreover, the estimation of SUV is quite sensitive to errors in the 
      measurements of body weight and injected dose. This study aims to develop an 
      image-based method to obtain an image-derived SUV (iSUV) and a modified SUV 
      (mSUV) to overcome these problems. METHODS: Thirty-one tumor-planted SCID mice 
      were scanned in micro-positron emission tomography (PET) at  approximately 60 min post FDG 
      injection and then scanned in micro-computed tomographic (CT). Using image-based 
      method, the body weight and injected dose were derived from the microPET/CT 
      images to calculate iSUV. The volumes and the total activities of FDG within the 
      bladder and the whole-body were also obtained to calculate mSUV. For the selected 
      targets, the iSUVs and mSUVs were compared against their corresponding SUVs. 
      RESULTS: Compared with SUV factor (injected dose/body weight), iSUV factor had an 
      average percentage error of -0.7%. The linear regressions between SUV and iSUV 
      had a slope of 0.99 with correlation coefficient of 0.95. Compared with SUV and 
      iSUV, coefficient of variation of mSUV decreased while the tumor-to-background 
      separation of mSUV increased. CONCLUSIONS: Using this image-based method, the 
      iSUV can replace SUV when the actual measurements were missing or unreliable. The 
      mSUV can reduce the inter-subject variability and enhance the tumor-to-background 
      separation in mouse FDG-PET studies.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Zheng, Xiujuan
AU  - Zheng X
AD  - Department of Electronic Information Engineering, the Hong Kong Polytechnic 
      University, Hung Hom, Kowloon, Hong Kong. zhengxj@eie.polyu.edu.hk
FAU - Yu, Chin-Lung
AU  - Yu CL
FAU - Sha, Wei
AU  - Sha W
FAU - Radu, Caius
AU  - Radu C
FAU - Huang, Sung-Cheng
AU  - Huang SC
FAU - Feng, Dagan
AU  - Feng D
LA  - eng
GR  - P50 CA086306/CA/NCI NIH HHS/United States
GR  - R01 EB001943/EB/NIBIB NIH HHS/United States
GR  - R01-EB001943/EB/NIBIB NIH HHS/United States
GR  - R01 EB001943-05A1/EB/NIBIB NIH HHS/United States
GR  - P50 CA086306-115375/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101203
PL  - United States
TA  - Nucl Med Biol
JT  - Nuclear medicine and biology
JID - 9304420
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - Diagnosis, Differential
MH  - Fluorodeoxyglucose F18/*metabolism
MH  - Image Processing, Computer-Assisted/*methods
MH  - Mice
MH  - Positron-Emission Tomography/*methods
PMC - PMC3078337
MID - NIHMS245882
EDAT- 2011/04/16 06:00
MHDA- 2011/08/24 06:00
PMCR- 2012/04/01
CRDT- 2011/04/16 06:00
PHST- 2010/06/09 00:00 [received]
PHST- 2010/08/19 00:00 [revised]
PHST- 2010/10/04 00:00 [accepted]
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - S0969-8051(10)00449-X [pii]
AID - 10.1016/j.nucmedbio.2010.10.002 [doi]
PST - ppublish
SO  - Nucl Med Biol. 2011 Apr;38(3):353-62. doi: 10.1016/j.nucmedbio.2010.10.002. Epub 
      2010 Dec 3.