PMID- 21493021
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110516
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 69
IP  - 2
DP  - 2011 Jun
TI  - The impact of obesity on diabetes mellitus and the role of bariatric surgery.
PG  - 137-40
LID - 10.1016/j.maturitas.2011.03.020 [doi]
AB  - Over 1.5 billion adults worldwide are classified as either overweight or obese, 
      with rates continuing to increase. Obese individuals are at an increased risk for 
      multiple disease processes, particularly type-2 diabetes mellitus (T2DM). Obesity 
      has a strong association with insulin resistance, hyperinsulinemia and glucose 
      intolerance. Adiposity, both subcutaneous and visceral, has been proposed to 
      contribute to insulin resistance, eventually leading to T2DM. Strong evidence 
      exists, in both genders, for the increased glucose intolerance and incidence of 
      T2DM with increasing weight gain. Conversely, weight loss is associated with 
      improvement of glycemic control, insulin resistance and T2DM. Bariatric surgery 
      has risen as a therapeutic option that provides exceptional reduction in overall 
      weight and resolution of T2DM. However, bariatric surgery serves as one component 
      of a multifaceted weight management strategy that is required for long-term 
      success.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Gill, Richdeep S
AU  - Gill RS
AD  - Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
FAU - Sharma, Arya M
AU  - Sharma AM
FAU - Gill, Sumeet S
AU  - Gill SS
FAU - Birch, Daniel W
AU  - Birch DW
FAU - Karmali, Shahzeer
AU  - Karmali S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110414
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - Adipose Tissue/*physiology
MH  - *Bariatric Surgery
MH  - Diabetes Mellitus, Type 2/complications/etiology/*surgery
MH  - Glucose Intolerance
MH  - Humans
MH  - Insulin Resistance
MH  - Obesity/complications/physiopathology/*surgery
MH  - Weight Gain/*physiology
MH  - Weight Loss/*physiology
EDAT- 2011/04/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/16 06:00
PHST- 2011/03/14 00:00 [received]
PHST- 2011/03/15 00:00 [accepted]
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0378-5122(11)00110-1 [pii]
AID - 10.1016/j.maturitas.2011.03.020 [doi]
PST - ppublish
SO  - Maturitas. 2011 Jun;69(2):137-40. doi: 10.1016/j.maturitas.2011.03.020. Epub 2011 
      Apr 14.