PMID- 21493043
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20220330
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 58
IP  - 1
DP  - 2011 Jul
TI  - Improvement effect on endothelial function in patients with congestive heart 
      failure treated with cardiac resynchronization therapy.
PG  - 69-73
LID - 10.1016/j.jjcc.2011.01.010 [doi]
AB  - BACKGROUND AND PURPOSE: Cardiac resynchronization therapy (CRT) is a beneficial 
      strategy to improve severe cardiac dysfunction in patients with congestive heart 
      failure (CHF). The improvement of endothelial function in CHF patients treated 
      with CRT is reflected in the mortality risk reduction. However the precise 
      mechanisms of the relationship between CRT and vascular endothelial function have 
      not been well discussed. METHODS AND SUBJECTS: Twenty-two severe consecutive CHF 
      patients associated with dilated cardiomyopathy [New York Heart Association 
      (NYHA) class 3.3 +/- 0.5, left ventricular ejection fraction (LVEF) 24.4 +/- 5.9%] 
      were included in this study. We evaluated endothelial function, measured by 
      reactive hyperemia peripheral arterial tonometry (RH-PAT), between optimal 
      medical therapy alone group (medical therapy group: n = 10) and CRT group (n = 
      12) at the study enrolment and 12 weeks later. Furthermore we analyzed the 
      association between the RH-PAT and cardiac function. ESSENTIAL RESULTS: Both 
      therapies significantly and equally improved NYHA class, LVEF, end-diastolic left 
      ventricular dimension and plasma levels of brain natriuretic peptide (BNP). CRT 
      significantly increased RH-PAT index (medical therapy group: 1.5 +/- 0.2 to 1.5 +/- 
      0.3, p = 0.824; CRT group: 1.4 +/- 0.2 to 1.7 +/- 0.4, p = 0.003) and cardiac output 
      (medical therapy group: 3.3 +/- 1.1 to 3.5 +/- 1.0, p = 0.600; CRT group: 2.7 +/- 0.6 
      to 4.3 +/- 1.5, p = 0.001), compared to the medical therapy group. There was 
      significant positive correlation between the change in RH-PAT index and cardiac 
      output (r = 0.600, p = 0.003). CONCLUSIONS: CRT significantly improved 
      endothelial function through the improvement of cardiac output in CHF patients, 
      compared to optimal medical therapy.
CI  - Copyright (c) 2011 Japanese College of Cardiology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Enomoto, Koji
AU  - Enomoto K
AD  - Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School 
      of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
FAU - Yamabe, Hiroshige
AU  - Yamabe H
FAU - Toyama, Kensuke
AU  - Toyama K
FAU - Matsuzawa, Yasushi
AU  - Matsuzawa Y
FAU - Yamamuro, Megumi
AU  - Yamamuro M
FAU - Uemura, Takashi
AU  - Uemura T
FAU - Morihisa, Kenji
AU  - Morihisa K
FAU - Iwashita, Satomi
AU  - Iwashita S
FAU - Kaikita, Koichi
AU  - Kaikita K
FAU - Sugiyama, Seigo
AU  - Sugiyama S
FAU - Ogawa, Hisao
AU  - Ogawa H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110413
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
SB  - IM
MH  - Cardiac Output/physiology
MH  - *Cardiac Resynchronization Therapy
MH  - Cardiomyopathy, Dilated/complications
MH  - Endothelium, Vascular/*physiology
MH  - Female
MH  - Heart Failure/drug therapy/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Manometry
MH  - Middle Aged
EDAT- 2011/04/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/16 06:00
PHST- 2010/11/28 00:00 [received]
PHST- 2011/01/12 00:00 [revised]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0914-5087(11)00013-X [pii]
AID - 10.1016/j.jjcc.2011.01.010 [doi]
PST - ppublish
SO  - J Cardiol. 2011 Jul;58(1):69-73. doi: 10.1016/j.jjcc.2011.01.010. Epub 2011 Apr 
      13.