PMID- 21493116
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20211020
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Print)
IS  - 1201-9712 (Linking)
VI  - 15
IP  - 6
DP  - 2011 Jun
TI  - Impact of the immune reconstitution inflammatory syndrome (IRIS) on mortality and 
      morbidity in HIV-infected patients in Mexico.
PG  - e408-14
LID - 10.1016/j.ijid.2011.02.007 [doi]
AB  - OBJECTIVES: To estimate the impact of immune reconstitution inflammatory syndrome 
      (IRIS) on morbidity and mortality in patients starting highly-active 
      antiretroviral therapy (HAART). METHODS: A retrospective cohort study of 
      HIV-positive patients starting HAART was conducted at a tertiary care referral 
      center in Mexico City. We estimated the incidence of IRIS, hospitalizations and 
      death rates during the first 2 years of HAART. The relative risk of death (RR) 
      and hospitalization for patients with IRIS were adjusted for relevant covariates 
      using regression methods. RESULTS: During the 2-year follow-up period, 27% of 
      patients developed IRIS (14 IRIS cases per 100 person-years). The relative risk 
      of death among patients who developed IRIS was 3 times higher (95% confidence 
      interval (CI) 1.19-7.65, p = 0.03). After adjusting for previous opportunistic 
      infections we still observed a higher death rate among patients with IRIS (RR 
      2.3, 95% CI 0.9-5.9, p=0.09). An effect modification of IRIS over mortality was 
      observed by previous opportunistic infection. CONCLUSIONS: IRIS-associated 
      mortality is strongly confounded by previous opportunistic infection. Patients 
      with AIDS who eventually developed IRIS had the highest risk of death at the 
      2-year follow-up.
CI  - Copyright (c) 2011 International Society for Infectious Diseases. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Hoyo-Ulloa, Irma
AU  - Hoyo-Ulloa I
AD  - Departamento de Infectologia, Instituto Nacional de Ciencias Medicas y Nutricion 
      Salvador Zubiran, Tlalpan, Mexico City, Mexico.
FAU - Belaunzaran-Zamudio, Pablo F
AU  - Belaunzaran-Zamudio PF
FAU - Crabtree-Ramirez, Brenda
AU  - Crabtree-Ramirez B
FAU - Galindo-Fraga, Arturo
AU  - Galindo-Fraga A
FAU - Perez-Aguinaga, Maria Eugenia
AU  - Perez-Aguinaga ME
FAU - Sierra-Madero, Juan G
AU  - Sierra-Madero JG
LA  - eng
GR  - U01 AI069923/AI/NIAID NIH HHS/United States
GR  - U01 AI069923-04/AI/NIAID NIH HHS/United States
GR  - 1 U01 AI069923/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110413
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
SB  - IM
MH  - AIDS-Related Opportunistic Infections/epidemiology/etiology/immunology
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active/*methods
MH  - Cohort Studies
MH  - Female
MH  - HIV Infections/complications/*drug therapy/epidemiology/*mortality
MH  - HIV-1/immunology
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*epidemiology/etiology/immunology
MH  - Incidence
MH  - Male
MH  - Mexico/epidemiology
MH  - Morbidity
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC3732828
MID - NIHMS284634
EDAT- 2011/04/16 06:00
MHDA- 2011/09/29 06:00
PMCR- 2013/08/04
CRDT- 2011/04/16 06:00
PHST- 2010/08/26 00:00 [received]
PHST- 2011/01/18 00:00 [revised]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PHST- 2013/08/04 00:00 [pmc-release]
AID - S1201-9712(11)00050-6 [pii]
AID - 10.1016/j.ijid.2011.02.007 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2011 Jun;15(6):e408-14. doi: 10.1016/j.ijid.2011.02.007. Epub 
      2011 Apr 13.