PMID- 21493923
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20220331
IS  - 1524-4571 (Electronic)
IS  - 0009-7330 (Linking)
VI  - 108
IP  - 8
DP  - 2011 Apr 15
TI  - The PPAR-RXR transcriptional complex in the vasculature: energy in the balance.
PG  - 1002-16
LID - 10.1161/CIRCRESAHA.110.226860 [doi]
AB  - The peroxisome proliferator-activated receptors (PPARs) and the retinoid X 
      receptors (RXRs) are ligand-activated transcription factors that coordinately 
      regulate gene expression. This PPAR-RXR transcriptional complex plays a critical 
      role in energy balance, including triglyceride metabolism, fatty acid handling 
      and storage, and glucose homeostasis: processes whose dysregulation characterize 
      obesity, diabetes, and atherosclerosis. PPARs and RXRs are also involved directly 
      in inflammatory and vascular responses in endothelial and vascular smooth muscle 
      cells. New insights into fundamental aspects of PPAR and RXR biology, and their 
      actions in the vasculature, continue to appear. Although RXRs are obligate 
      heterodimeric partners for PPAR action, the part that RXRs, and their endogenous 
      retinoid mediators, exert in the vessel wall is less well understood. Biological 
      insights into PPAR-RXRs may help inform interpretation of clinical trials with 
      synthetic PPAR agonists and prospects for future PPAR therapeutics. Importantly, 
      the extensive data establishing a key role for PPARs and RXRs in energy balance, 
      inflammation, and vascular biology stands separately from the clinical experience 
      with any given synthetic PPAR agonist. Both the basic science data and the 
      clinical experience with PPAR agonists identify the need to better understand 
      these important transcriptional regulators.
FAU - Plutzky, Jorge
AU  - Plutzky J
AD  - Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA. 
      jplutzky@rics.bwh.harvard.edu
LA  - eng
GR  - AR054604-03S1/AR/NIAMS NIH HHS/United States
GR  - HL048743/HL/NHLBI NIH HHS/United States
GR  - HL075771/HL/NHLBI NIH HHS/United States
GR  - HL095123/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Circ Res
JT  - Circulation research
JID - 0047103
RN  - 0 (Peroxisome Proliferator-Activated Receptors)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/metabolism/physiopathology
MH  - Energy Metabolism/*physiology
MH  - Humans
MH  - Muscle, Smooth, Vascular/*metabolism
MH  - Peroxisome Proliferator-Activated Receptors/*metabolism
MH  - Retinoid X Receptors/*metabolism/physiology
MH  - Transcription Factors/metabolism/physiology
MH  - Transcription, Genetic/physiology
EDAT- 2011/04/16 06:00
MHDA- 2011/06/17 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 108/8/1002 [pii]
AID - 10.1161/CIRCRESAHA.110.226860 [doi]
PST - ppublish
SO  - Circ Res. 2011 Apr 15;108(8):1002-16. doi: 10.1161/CIRCRESAHA.110.226860.