PMID- 21494994
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20220331
IS  - 1439-359X (Electronic)
IS  - 0939-7248 (Linking)
VI  - 21
IP  - 2
DP  - 2011 Mar
TI  - The use of TachoSil in children undergoing liver resection with or without 
      segmental liver transplantation.
PG  - 111-5
LID - 10.1055/s-0030-1267221 [doi]
AB  - INTRODUCTION: Local haemostatic agents are used for the control of surgical 
      haemorrhage when standard techniques are inadequate, but there are few studies of 
      these products in children. PATIENTS AND METHODS: This was a prospective, 
      open-label study in which children (aged 4 weeks to 6 years) undergoing liver 
      resection with or without segmental liver transplantation were treated with 
      TachoSil, a collagen patch coated with a dry layer of human fibrinogen and human 
      thrombin, if minor (i. e., oozing) or moderate bleeding was present after primary 
      haemostatic treatment. Time to haemostasis after TachoSil application was the 
      primary endpoint. Safety was assessed by adverse events (AEs), including 
      post-operative infections, symptoms of graft rejection and re-operations. 
      RESULTS: Enrolment was stopped early after 16 children had entered the study. 13 
      children underwent whole liver resection and transplantation and 3 patients 
      underwent segmental resection. Satisfactory haemostasis was achieved in 13 
      children (81.3%; 95% CI: 61.8-100%) at 3 min and in 1 child at 8 min. Occurrence 
      of AEs was as expected, with most being known complications of the underlying 
      disease, surgical procedure, or use of immunosuppressive medication. No AEs were 
      considered to be related to the use of TachoSil. CONCLUSIONS: The use of TachoSil 
      for haemostasis after primary haemostatic treatment appears to be safe and 
      effective in children undergoing liver resection.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Mirza, D
AU  - Mirza D
AD  - Birmingham Children's Hospital, The Liver Unit, Birmingham, United Kingdom. 
      darius.mirza@uhb.nhs.uk
FAU - Millar, A J W
AU  - Millar AJ
FAU - Sharif, K
AU  - Sharif K
FAU - Vilca-Melendez, H
AU  - Vilca-Melendez H
FAU - Rela, M
AU  - Rela M
FAU - Heaton, N
AU  - Heaton N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20110414
PL  - United States
TA  - Eur J Pediatr Surg
JT  - European journal of pediatric surgery : official journal of Austrian Association 
      of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
JID - 9105263
RN  - 0 (Drug Combinations)
RN  - 0 (TachoSil)
RN  - 9001-32-5 (Fibrinogen)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Blood Loss, Surgical/*prevention & control
MH  - Child
MH  - Child, Preschool
MH  - Drug Combinations
MH  - Fibrinogen/*pharmacology
MH  - Follow-Up Studies
MH  - Hemostasis, Surgical/*instrumentation
MH  - Hepatectomy/*methods
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Liver Diseases/surgery
MH  - Liver Transplantation/*methods
MH  - Prospective Studies
MH  - Surgical Sponges
MH  - Thrombin/*pharmacology
MH  - Treatment Outcome
EDAT- 2011/04/16 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 10.1055/s-0030-1267221 [doi]
PST - ppublish
SO  - Eur J Pediatr Surg. 2011 Mar;21(2):111-5. doi: 10.1055/s-0030-1267221. Epub 2011 
      Apr 14.