PMID- 21496383
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20220331
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 24
IP  - 1
DP  - 2011 Jan-Mar
TI  - Correlations of serum Interleukin-16, total IgE, eosinophil cationic protein and 
      total eosinophil counts with disease activity in children with atopic dermatitis.
PG  - 15-23
AB  - Several laboratory parameters have been investigated for assessing disease 
      activity in children with atopic dermatitis (AD). Analyses of the correlation 
      between these parameters and clinical severity can help to choose a convincing 
      tool. This study compared the significance of serum interleukin-16 (IL-16), serum 
      total immunoglobulin E (IgE), serum eosinophil cationic protein (ECP), and total 
      eosinophil count (TEC) in reflecting AD severity to order to identify the most 
      relevant objective tool for assessing AD activity and to assess the correlation 
      between these laboratory parameters. The Severity Scoring of Atopic Dermatitis 
      (SCORAD index) was used for the assessment of disease activity in 48 pediatric 
      patients in the acute exacerbation phase and in the maintenance phase after 
      improvement of clinical findings with conventional treatment for 8 weeks. Serum 
      levels of total IgE, ECP, and IL-16 as well as TEC were measured on the same time 
      points and compared with healthy non-atopic controls. The correlation between 
      SCORAD and each laboratory parameter was tested for significance and compared. 
      Serum levels of ECP and IL-16 of AD patients were significantly higher than those 
      of controls. These serum parameters, except TEC, declined significantly after 
      conventional treatment with clinical improvement. There was positive correlation 
      with SCORAD for serum IgE (r=0.317, p=0.028), TEC(r=0.434, p=0.002), IL-16 (r = 
      0.321, p=0.026) in the acute exacerbation phase and with SCORAD for serum IgE 
      (r=0.510, p<0.001), TEC(r=0.489, p<0.001), serum ECP (r=0.468, p=0.001) in the 
      maintenance phase. Serum levels of total IgE, IL-16, ECP, and TEC correlated with 
      the SCORAD index in pediatric patients with atopic dermatitis. Thus, they can 
      serve as serum markers for monitoring disease activity in childhood atopic 
      dermatitis.
FAU - Wu, K-G
AU  - Wu KG
AD  - Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan. 
      kgwu@vghtpe.gov.tw
FAU - Li, T-H
AU  - Li TH
FAU - Chen, C-J
AU  - Chen CJ
FAU - Cheng, H-I
AU  - Cheng HI
FAU - Wang, T-Y
AU  - Wang TY
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-16)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Adolescent
MH  - Biomarkers
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*immunology
MH  - Eosinophil Cationic Protein/*blood
MH  - Eosinophils/*physiology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Interleukin-16/*blood
MH  - Leukocyte Count
MH  - Male
EDAT- 2011/04/19 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/04/19 06:00
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 3 [pii]
AID - 10.1177/039463201102400103 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):15-23. doi: 
      10.1177/039463201102400103.