PMID- 21497490
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 0165-1781 (Print)
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 192
IP  - 2
DP  - 2011 May 31
TI  - Hypo-activation in the executive core of the sustained attention network in 
      adolescent offspring of schizophrenia patients mediated by premorbid functional 
      deficits.
PG  - 91-9
LID - 10.1016/j.pscychresns.2010.12.005 [doi]
AB  - Adolescent offspring of schizophrenia patients (SCZ-Off) are vulnerable to 
      psychiatric disorders. Assessing relationships between clinical and biological 
      measures (such as functional magnetic resonance imaging, fMRI) may elucidate 
      pathways of vulnerability in this group. Here we assessed the relationship 
      between clinically assessed premorbid function, and cortico-striatal activity 
      during sustained attention in controls (HC: with no family history of psychosis) 
      and SCZ-Off. Subjects (n=39) were assessed using the Structured Interview for 
      Prodromal Syndromes and the Scale of Prodromal Symptoms. Based on the Global 
      Assessment of Functioning (GAF) score, SCZ-Off were cleaved into "high" or "low" 
      clinically functioning sub-groups (SCZ-Off(HF), SCZ-Off(LF) respectively). During 
      fMRI, subjects participated in a modified continuous performance task (CPT-IP). 
      fMRI was conducted on a Bruker MedSpec 4T system (345 EPI scans; TR=2s; 24 
      slices; 3.8x3.8x4mm). Results show SCZ-Off(LF) evinced less activation than both 
      HC and SCZ-Off(HF) in the executive core of the brain's attentional system 
      (anterior cingulate, dorsal prefrontal cortex and caudate), but not visuo-spatial 
      regions such as primary visual or superior parietal cortex. Differences were 
      independent of behavioral performance, and reduction in activity was related to 
      GAF score in a dose-dependent manner. Assessing the relationship between clinical 
      measures and brain activity in domains such as attention provides a window into 
      mechanisms of vulnerability in the developing adolescent brain.
CI  - 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Diwadkar, Vaibhav A
AU  - Diwadkar VA
AD  - Department of Psychiatry & Behavioral Neuroscience, Wayne State University, 
      Detroit, MI 48201, USA. vdiwadka@med.wayne.edu
FAU - Segel, Jamie
AU  - Segel J
FAU - Pruitt, Patrick
AU  - Pruitt P
FAU - Murphy, Eric R
AU  - Murphy ER
FAU - Keshavan, Matcheri S
AU  - Keshavan MS
FAU - Radwan, Jacqueline
AU  - Radwan J
FAU - Rajan, Usha
AU  - Rajan U
FAU - Zajac-Benitez, Caroline
AU  - Zajac-Benitez C
LA  - eng
GR  - K01 MH068680/MH/NIMH NIH HHS/United States
GR  - K01 MH068680-01/MH/NIMH NIH HHS/United States
GR  - MH68680/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110415
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Attention/*physiology
MH  - Brain/blood supply/*pathology
MH  - Brain Mapping
MH  - Child
MH  - Disabled Children/*psychology
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Neural Pathways/blood supply/pathology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Psychiatric Status Rating Scales
MH  - *Schizophrenia
MH  - *Schizophrenic Psychology
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC3085585
MID - NIHMS260909
EDAT- 2011/04/19 06:00
MHDA- 2011/06/29 06:00
PMCR- 2012/05/31
CRDT- 2011/04/19 06:00
PHST- 2010/06/02 00:00 [received]
PHST- 2010/11/24 00:00 [revised]
PHST- 2010/12/09 00:00 [accepted]
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PHST- 2012/05/31 00:00 [pmc-release]
AID - S0925-4927(10)00427-0 [pii]
AID - 10.1016/j.pscychresns.2010.12.005 [doi]
PST - ppublish
SO  - Psychiatry Res. 2011 May 31;192(2):91-9. doi: 10.1016/j.pscychresns.2010.12.005. 
      Epub 2011 Apr 15.