PMID- 21497550 OWN - NLM STAT- MEDLINE DCOM- 20120209 LR - 20181201 IS - 1444-2892 (Electronic) IS - 1443-9506 (Linking) VI - 20 IP - 9 DP - 2011 Sep TI - Mitral valve repair or replacement for ischaemic mitral regurgitation: a systematic review. PG - 555-65 LID - 10.1016/j.hlc.2011.03.012 [doi] AB - A literature review was undertaken according to Cochrane guidelines to identify whether mitral valve repair (MV-Repair) or replacement (MV-Replacement) is more effective in patients with moderate to severe ischaemic mitral regurgitation. The literature suggests MV-Repair may have improved 30-day mortality and long-term survival. All 12 studies identified, however, were non-randomised, retrospective, and at significant risk of bias due to heterogeneous surgical techniques and mismatched patient characteristics. Data describing the need for reoperation were not sufficiently well reported to analyse. Functional outcomes and health-related quality of life were not reported. In conclusion, high-quality randomised comparison of MV-Repair and MV-Replacement is urgently needed. CI - Copyright (c) 2011 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier B.V. All rights reserved. FAU - Rao, Christopher AU - Rao C AD - Department of Biosurgery and Surgical Technology, Imperial College London, 10th Floor QEQM Building, St Mary's Hospital, London W2 1NY, UK. FAU - Murphy, Michael O AU - Murphy MO FAU - Saso, Srdjan AU - Saso S FAU - Pandis, Dimosthenis AU - Pandis D FAU - Grapsa, Julia AU - Grapsa J FAU - Nihoyannopoulos, Petros AU - Nihoyannopoulos P FAU - Reeves, Barnaby C AU - Reeves BC FAU - Athanasiou, Thanos AU - Athanasiou T LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20110416 PL - Australia TA - Heart Lung Circ JT - Heart, lung & circulation JID - 100963739 SB - IM MH - *Heart Valve Prosthesis MH - Humans MH - Mitral Valve/*surgery MH - Mitral Valve Insufficiency/*mortality/*surgery MH - Survival Rate MH - Time Factors EDAT- 2011/04/19 06:00 MHDA- 2012/02/10 06:00 CRDT- 2011/04/19 06:00 PHST- 2010/10/06 00:00 [received] PHST- 2011/01/17 00:00 [revised] PHST- 2011/03/18 00:00 [accepted] PHST- 2011/04/19 06:00 [entrez] PHST- 2011/04/19 06:00 [pubmed] PHST- 2012/02/10 06:00 [medline] AID - S1443-9506(11)00138-7 [pii] AID - 10.1016/j.hlc.2011.03.012 [doi] PST - ppublish SO - Heart Lung Circ. 2011 Sep;20(9):555-65. doi: 10.1016/j.hlc.2011.03.012. Epub 2011 Apr 16.