PMID- 21497673
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20211020
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 155
IP  - 1
DP  - 2012 Jan
TI  - Unique ionotropic receptors for D-aspartate are a target for serotonin-induced 
      synaptic plasticity in Aplysia californica.
PG  - 151-9
LID - 10.1016/j.cbpc.2011.04.001 [doi]
AB  - The non-L-glutamate (L-Glu) receptor component of D-aspartate (D-Asp) currents in 
      Aplysia californica buccal S cluster (BSC) neurons was studied with whole cell 
      voltage clamp to differentiate it from receptors activated by other well-known 
      agonists of the Aplysia nervous system and investigate modulatory mechanisms of 
      D-Asp currents associated with synaptic plasticity. Acetylcholine (ACh) and 
      serotonin (5-HT) activated whole cell excitatory currents with similar current 
      voltage relationships to D-Asp. These currents, however, were pharmacologically 
      distinct from D-Asp. ACh currents were blocked by hexamethonium (C6) and 
      tubocurarine (D-TC), while D-Asp currents were unaffected. 5-HT currents were 
      blocked by granisetron and methysergide (MES), while D-Asp currents were 
      unaffected. Conversely, while 
      (2S,3R)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid(PPDA) blocked 
      D-Asp currents, it had no effect on ACh or 5-HT currents. Comparison of the 
      charge area described by currents induced by ACh or 5-HT separately from, or 
      with, D-Asp suggests activation of distinct receptors by all 3 agonists. Charge 
      area comparisons with L-Glu, however, suggested some overlap between L-Glu and 
      D-Asp receptors. Ten minute exposure to 5-HT induced facilitation of D-Asp-evoked 
      responses in BSC neurons. This effect was mimicked by phorbol ester, suggesting 
      that protein kinase C (PKC) was involved.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Carlson, Stephen L
AU  - Carlson SL
AD  - University of Miami Rosenstiel School of Marine and Atmospheric Science, Division 
      of Marine Biology and Fisheries, Miami, FL 33149, USA.
FAU - Fieber, Lynne A
AU  - Fieber LA
LA  - eng
GR  - P40 OD010952/OD/NIH HHS/United States
GR  - P40 RR010294/RR/NCRR NIH HHS/United States
GR  - P40 RR010294-11/RR/NCRR NIH HHS/United States
GR  - P40RR01029/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110409
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Diazonium Compounds)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, Ionotropic Glutamate)
RN  - 117141-32-9 (4-(2'-pyridyldithio)benzyldiazoacetate)
RN  - 333DO1RDJY (Serotonin)
RN  - 3C9PSP36Z2 (Hexamethonium)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 4SR0Q8YD1X (D-Aspartic Acid)
RN  - N9YNS0M02X (Acetylcholine)
RN  - W9YXS298BM (Tubocurarine)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Animals
MH  - Aplysia/*drug effects/metabolism/physiology
MH  - D-Aspartic Acid/metabolism/*pharmacology
MH  - Diazonium Compounds/pharmacology
MH  - Ganglia, Invertebrate/drug effects/metabolism
MH  - Glutamic Acid/pharmacology
MH  - Hexamethonium/pharmacology
MH  - Nervous System Physiological Phenomena
MH  - Neurons/drug effects
MH  - Patch-Clamp Techniques
MH  - Pyridines/pharmacology
MH  - Receptors, Ionotropic Glutamate/*metabolism/physiology
MH  - Serotonin/*pharmacology
MH  - *Synaptic Transmission
MH  - Tubocurarine/pharmacology
PMC - PMC3155736
MID - NIHMS290214
EDAT- 2011/04/19 06:00
MHDA- 2012/03/06 06:00
PMCR- 2013/01/01
CRDT- 2011/04/19 06:00
PHST- 2011/01/17 00:00 [received]
PHST- 2011/03/30 00:00 [revised]
PHST- 2011/04/01 00:00 [accepted]
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - S1532-0456(11)00059-7 [pii]
AID - 10.1016/j.cbpc.2011.04.001 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2012 Jan;155(1):151-9. doi: 
      10.1016/j.cbpc.2011.04.001. Epub 2011 Apr 9.