PMID- 21497984
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110613
IS  - 1432-0436 (Electronic)
IS  - 0301-4681 (Linking)
VI  - 81
IP  - 5
DP  - 2011 Jun
TI  - Tenascin C may regulate the recruitment of smooth muscle cells during coronary 
      artery development.
PG  - 299-306
LID - 10.1016/j.diff.2011.03.002 [doi]
AB  - Tenascin C (TNC) is an extracellular glycoprotein that is thought to be involved 
      in tissue remodeling during organogenesis and regeneration. Using avian embryonic 
      hearts, we investigated the spatiotemporal expression patterns of TNC during the 
      formation of the proximal coronary artery. Immunohistochemistry showed that TNC 
      was deposited around the developing coronary stem and that TNC colocalized with 
      vascular smooth muscle alpha-actin. A quail-chick chimera, in which a quail 
      proepicardial organ (PEO) had been transplanted, showed that quail tissue-derived 
      cells contributed to the establishment of the endothelial and mural cells of the 
      proximal coronary artery, and the quail tissue-derived mural cells displayed TNC. 
      Proepicardial cells cultured in TNC showed the myofibroblast/smooth muscle cell 
      phenotype and neutralizing anti-TNC antibody suppressed the expression of smooth 
      muscle markers. These observations suggest that TNC plays a role in the mural 
      smooth muscle development of the nascent proximal coronary artery.
CI  - Copyright (c) 2011 International Society of Differentiation. Published by Elsevier 
      B.V. All rights reserved.
FAU - Ando, Katsumi
AU  - Ando K
AD  - Health Sciences Saitama Prefectural University, Japan.
FAU - Takahashi, Makiko
AU  - Takahashi M
FAU - Yamagishi, Toshiyuki
AU  - Yamagishi T
FAU - Miyagawa-Tomita, Sachiko
AU  - Miyagawa-Tomita S
FAU - Imanaka-Yoshida, Kyoko
AU  - Imanaka-Yoshida K
FAU - Yoshida, Toshimichi
AU  - Yoshida T
FAU - Nakajima, Yuji
AU  - Nakajima Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110416
PL  - England
TA  - Differentiation
JT  - Differentiation; research in biological diversity
JID - 0401650
RN  - 0 (Actins)
RN  - 0 (Tenascin)
SB  - IM
MH  - Actins/*metabolism
MH  - Animals
MH  - Cell Culture Techniques
MH  - Cell Differentiation/physiology
MH  - Chick Embryo
MH  - Coronary Vessels/*embryology/*metabolism
MH  - Heart/embryology
MH  - Immunohistochemistry/methods
MH  - Muscle Development
MH  - Muscle, Smooth, Vascular/cytology/*metabolism
MH  - Organogenesis
MH  - Pericardium/*cytology/embryology/metabolism
MH  - Quail
MH  - Tenascin/biosynthesis/*genetics/*metabolism
EDAT- 2011/04/19 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/19 06:00
PHST- 2010/10/12 00:00 [received]
PHST- 2011/03/18 00:00 [revised]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0301-4681(11)00047-8 [pii]
AID - 10.1016/j.diff.2011.03.002 [doi]
PST - ppublish
SO  - Differentiation. 2011 Jun;81(5):299-306. doi: 10.1016/j.diff.2011.03.002. Epub 
      2011 Apr 16.