PMID- 21500426 OWN - NLM STAT- MEDLINE DCOM- 20110512 LR - 20111117 IS - 1026-3543 (Print) IS - 1026-3543 (Linking) VI - 137 IP - 5 DP - 2010 TI - [Analysis of morphological manifestations of the inflammatory reaction in wistar rat spinal cord in experimental model]. PG - 16-20 AB - Morphological changes in the spinal cord of rats with different intensity of pathological symptoms were studied at the peak of the experimental encephalomyelitis development. Light-microscopical and immunohistochemical methods were used. Distribution of proliferating cell nuclear antigen (PCNA), astrocyte marker - glial fibrillar acidic protein (GFAP), and microglia and macrophage marker Iba-1, was studied. Heterogeneity in morphological manifestations of the experimental allergic encephalomyelitis was shown. Four typical patterns of morphological manifestations of the disease were demonstrated depending on the preferential involvement of pia mater, vessels, spinal cell nuclei or conductive tracts in the pathological process. FAU - Gilerovich, E G AU - Gilerovich EG FAU - Fedorova, E A AU - Fedorova EA FAU - Abdurasulova, I N AU - Abdurasulova IN FAU - Karpenko, M N AU - Karpenko MN FAU - Sokolov, A V AU - Sokolov AV FAU - Zakharova, E T AU - Zakharova ET FAU - Zhitnukhin, Iu L AU - Zhitnukhin IuL FAU - Korzhevskii, D E AU - Korzhevskii DE FAU - Vasil'ev, V B AU - Vasil'ev VB LA - rus PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Russia (Federation) TA - Morfologiia JT - Morfologiia (Saint Petersburg, Russia) JID - 9317610 RN - 0 (Aif1 protein, rat) RN - 0 (Calcium-Binding Proteins) RN - 0 (Microfilament Proteins) RN - 0 (Nerve Tissue Proteins) RN - 0 (Proliferating Cell Nuclear Antigen) SB - IM MH - Animals MH - Calcium-Binding Proteins/biosynthesis/immunology MH - Encephalomyelitis, Autoimmune, Experimental/immunology/metabolism/*pathology MH - Female MH - Microfilament Proteins MH - Myelitis/immunology/metabolism/*pathology MH - Nerve Tissue Proteins/biosynthesis/immunology MH - Proliferating Cell Nuclear Antigen/biosynthesis/immunology MH - Rats MH - Rats, Wistar MH - Spinal Cord/immunology/metabolism/*pathology EDAT- 2010/01/01 00:00 MHDA- 2011/05/13 06:00 CRDT- 2011/04/20 06:00 PHST- 2011/04/20 06:00 [entrez] PHST- 2010/01/01 00:00 [pubmed] PHST- 2011/05/13 06:00 [medline] PST - ppublish SO - Morfologiia. 2010;137(5):16-20.