PMID- 21500918
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20131121
IS  - 1931-1559 (Electronic)
IS  - 0894-4105 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Sep
TI  - Differential effects of prenatal testosterone on lateralization of handedness and 
      language.
PG  - 581-9
LID - 10.1037/a0023293 [doi]
AB  - OBJECTIVE: Handedness is the most noticeable functional expression of cerebral 
      lateralization in humans. However, its developmental process and plasticity 
      remain elusive. It has been postulated that prenatal testosterone (pT) has an 
      effect on human lateralization development. In the present study we examined the 
      relationship between pT and handedness and compared the outcome to previously 
      published data on language lateralization in the same children. METHOD: pT was 
      assessed from amniotic fluid of healthy pregnant women using radioimmunoassay. 
      Strength and direction of handedness of the children (n = 65 [31 girls, 34 boys], 
      mean age [years]: 6.43, range: 5.97-7.53) was assessed based on hand choice 
      during performance of age appropriate tasks. Regression procedures and the Olkin 
      & Siotani Z-statistic were used. RESULTS: Results demonstrate that higher pT 
      exposure was related to a decrease in strength of handedness (R(2) = .11, p = .01). 
      The analysis shows that pT has quite stronger explanatory power than sex by 
      itself, although there may be an additional effect of sex independent from pT. In 
      a subgroup of these children we recently reported that higher levels of pT are 
      related to increased left hemisphere dominance for language. Analyses show that 
      pT is differentially related to handedness and language lateralization in these 
      children (Z > 2.75, p < .003). CONCLUSIONS: Results imply a differential effect 
      of pT on language lateralization and handedness. This may be explained by 
      differential sensitivity of different areas of the corpus callosum or hemispheres 
      for androgens, fuelling the ongoing debate about the relationship between 
      prenatal exposure to testosterone and lateralization of brain and behavior.
CI  - PsycINFO Database Record (c) 2011 APA, all rights reserved.
FAU - Lust, Jessica M
AU  - Lust JM
AD  - Department of Clinical and Developmental Neuropsychology, University of 
      Groningen, Groningen, the Netherlands. J.M.Lust@rug.nl
FAU - Geuze, Reint H
AU  - Geuze RH
FAU - Van de Beek, Cornelieke
AU  - Van de Beek C
FAU - Cohen-Kettenis, Peggy T
AU  - Cohen-Kettenis PT
FAU - Bouma, Anke
AU  - Bouma A
FAU - Groothuis, Ton G G
AU  - Groothuis TG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuropsychology
JT  - Neuropsychology
JID - 8904467
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Amniotic Fluid/chemistry
MH  - Child
MH  - Child, Preschool
MH  - Dichotic Listening Tests
MH  - Dominance, Cerebral/physiology
MH  - Female
MH  - Fetal Development/*physiology
MH  - Functional Laterality/*physiology
MH  - Humans
MH  - *Language
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Reference Values
MH  - Statistics, Nonparametric
MH  - Testosterone/analysis/*physiology
EDAT- 2011/04/20 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - 2011-07887-001 [pii]
AID - 10.1037/a0023293 [doi]
PST - ppublish
SO  - Neuropsychology. 2011 Sep;25(5):581-9. doi: 10.1037/a0023293.