PMID- 21501002
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20220311
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 27
IP  - 8
DP  - 2011 Aug
TI  - Adult height, body mass index and time of menarche of girls with idiopathic 
      central precocious puberty after gonadotropin-releasing hormone analogue 
      treatment.
PG  - 524-8
LID - 10.3109/09513590.2010.507289 [doi]
AB  - BACKGROUND: Long-term outcome data of central precocious puberty (CPP) girls 
      treated with gonadotropin-releasing hormone analogue (GnRHa) are conflicting. 
      AIM: To assess long-term outcome of girls with idiopathic CPP (iCPP) treated with 
      GnRHa. METHODS: We compared adult height (AH), body mass index (BMI) and time of 
      menarche in GnRHa-treated (n = 47) and untreated (n = 11) girls with iCPP. 
      RESULTS: There were no differences in age, bone age, height, weight and BMI 
      z-scores, predicted adult height (PAH) at the time of diagnosis and target height 
      between the two groups. Mean (SD) age of GnRHa-treated girls was 8.5 (1.0) years 
      at the start of treatment. Mean (SD) AH of the treated group was greater [158.6 
      (5.2) vs. 154.8 (5.6) cm], p < 0.05. AH gain over pre-treatment PAH in the 
      treated group was 4.7 cm. BMI z-score of treated girls was 1.26 (0.95) before the 
      treatment initiated and returned to normal [0.16 (1.0)] at the time of AH 
      reached. Menstruation occurred at 0.9 (0.5) years following GnRHa discontinuation 
      with regular pattern. CONCLUSIONS: Long-term GnRHa therapy has a modest 
      beneficial effect on adult height gain in girls with iCPP. No detrimental effects 
      on increasing BMI and hypothalamic-pituitary-gonadal axis reactivation are 
      demonstrated.
FAU - Poomthavorn, Preamrudee
AU  - Poomthavorn P
AD  - Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok, 10400, Thailand.
FAU - Suphasit, Ratchadaporn
AU  - Suphasit R
FAU - Mahachoklertwattana, Pat
AU  - Mahachoklertwattana P
LA  - eng
PT  - Journal Article
DEP - 20110418
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
SB  - IM
MH  - Adolescent
MH  - Adolescent Development/drug effects
MH  - Body Height/*drug effects
MH  - Body Mass Index
MH  - Body Weight/*drug effects
MH  - Child
MH  - Child Development/drug effects
MH  - Female
MH  - Follow-Up Studies
MH  - Gonadotropin-Releasing Hormone/administration & dosage/adverse effects/*analogs & 
      derivatives/therapeutic use
MH  - Growth Disorders/etiology/*prevention & control
MH  - Humans
MH  - Menarche/*drug effects
MH  - Puberty, Precocious/*drug therapy/physiopathology
EDAT- 2011/04/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.3109/09513590.2010.507289 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2011 Aug;27(8):524-8. doi: 10.3109/09513590.2010.507289. Epub 
      2011 Apr 18.