PMID- 21501120
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20211203
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 78
IP  - 1
DP  - 2011 Jul
TI  - HLA-A, HLA-B, and HLA-DRB1 allele distribution in a large Armenian population 
      sample.
PG  - 21-30
LID - 10.1111/j.1399-0039.2011.01668.x [doi]
AB  - Human leukocyte antigen (HLA)-A, HLA-B, and HLA-DRB1 gene frequencies were 
      investigated in 4279 unrelated Armenian bone marrow donors. HLA alleles were 
      defined by using PCR amplification with sequence specific primers (PCR-SSP) high- 
      and low-resolution kits. The aim of this study was to examine the HLA diversity 
      at the high-resolution level in a large Armenian population sample, and to 
      compare HLA allele group distribution in Armenian subpopulations. The most 
      frequently observed alleles in the HLA class I were HLA-A*0201, A*0101, A*2402, 
      A*0301, HLA-B*5101, HLA-B*3501, and B*4901. Among DRB1 alleles, high frequencies 
      of DRB1*1104 and DRB1*1501 were observed, followed by DRB1*1101 and DRB1*1401. 
      The most common three-locus haplotype found in the Armenian population was 
      A*33-B*14-DRB1*01, followed by A*03-B*35-DRB1*01. Our results show a similar 
      distribution of alleles in Armenian subpopulations from different countries, and 
      from different regions of the Republics of Armenia and Karabagh. The low level of 
      genetic distances between subpopulations indicates a high level of population 
      homogeneity, and the genetic distances between Armenians and other populations 
      show Armenians as a distinct ethnic group relative to others, reflecting the fact 
      that Armenians have been an 'isolated population' throughout centuries. This 
      study is the first comprehensive investigation of HLA-allele group distribution 
      in a subset of Armenian populations, and the first to provide HLA-allele and 
      haplotype frequencies at a high-resolution level. It is a valuable reference for 
      organ transplantation and for future studies of HLA-associated diseases in 
      Armenian populations.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Matevosyan, L
AU  - Matevosyan L
AD  - Armenian Bone Marrow Donors Registry, Yerevan, Republic of Armenia.
FAU - Chattopadhyay, S
AU  - Chattopadhyay S
FAU - Madelian, V
AU  - Madelian V
FAU - Avagyan, S
AU  - Avagyan S
FAU - Nazaretyan, M
AU  - Nazaretyan M
FAU - Hyussian, A
AU  - Hyussian A
FAU - Vardapetyan, E
AU  - Vardapetyan E
FAU - Arutunyan, R
AU  - Arutunyan R
FAU - Jordan, F
AU  - Jordan F
LA  - eng
PT  - Journal Article
DEP - 20110419
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Armenia/epidemiology/ethnology
MH  - Ethnicity/genetics
MH  - Gene Frequency
MH  - Genetic Variation
MH  - Genetics, Population
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Iran/epidemiology
MH  - Lebanon/epidemiology
MH  - Population Groups/genetics
MH  - United States/epidemiology
EDAT- 2011/04/20 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
AID - 10.1111/j.1399-0039.2011.01668.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2011 Jul;78(1):21-30. doi: 10.1111/j.1399-0039.2011.01668.x. 
      Epub 2011 Apr 19.