PMID- 21501303
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20160511
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 53
IP  - 2
DP  - 2011 Apr
TI  - Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps 
      meningitis in children.
PG  - 143-6
LID - 10.1111/j.1442-200X.2010.03215.x [doi]
AB  - BACKGROUND:   The mumps virus is frequently the causative agent in aseptic 
      meningitis and mumps has still prevailed in Japan. We compared data obtained from 
      patients with mumps meningitis and patients with aseptic meningitis caused by 
      other viruses in order to identify mumps meningitis-specific cytokine/chemokine 
      alterations in cerebrospinal fluid (CSF). METHODS:   We elucidated the 
      cytokine/chemokine network based on the cytokine/chemokine profiles in CSF from 
      children with mumps meningitis and meningitis due to other viral infections using 
      multiplex cytokine measurement. Seventeen cytokines/chemokines, namely 
      interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), 
      IL-13, IL-17, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, granulocyte 
      colony-stimulating factor (G-CSF), granulocyte monocyte colony-stimulating factor 
      (GM-CSF), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory 
      protein-1beta (MIP-1beta), were measured simultaneously in CSF supernatants from eight 
      children with mumps meningitis, 11 children with other types of viral meningitis 
      and eight children with fever without neurological complications such as 
      convulsion. RESULTS:   We found that IL-8, IL-10, IL-12, IL-13 and IFN-gamma showed a 
      statistically significant increase in CSF from mumps meningitis when compared to 
      other types of viral meningitis and fever without neurological complications. 
      CONCLUSION:   Mumps meningitis may induce a distinct immunological response when 
      compared with other types of viral meningitis.
CI  - (c) 2011 The Authors.Pediatrics International (c) 2011 Japan Pediatric Society.
FAU - Asano, Takeshi
AU  - Asano T
AD  - Departments of Pediatrics Emergency and Critical Care Medicine, Nippon Medical 
      School, Chiba Hokusoh Hospital, Chiba, Japan. vff13540@nifty.ne.jp
FAU - Ichiki, Kunihiko
AU  - Ichiki K
FAU - Koizumi, Shinya
AU  - Koizumi S
FAU - Kaizu, Kiyohiko
AU  - Kaizu K
FAU - Hatori, Takayuki
AU  - Hatori T
FAU - Fujino, Osamu
AU  - Fujino O
FAU - Mashiko, Kunihiro
AU  - Mashiko K
FAU - Sakamoto, Yuichiro
AU  - Sakamoto Y
FAU - Miyasho, Taku
AU  - Miyasho T
FAU - Fukunaga, Yoshitaka
AU  - Fukunaga Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Interleukins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Chemokine CCL2/cerebrospinal fluid
MH  - Chemokine CCL4/cerebrospinal fluid
MH  - Chemokines/*cerebrospinal fluid
MH  - Child
MH  - Cytokines/*cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Interferon-gamma/cerebrospinal fluid
MH  - Interleukins/cerebrospinal fluid
MH  - Male
MH  - Meningitis, Aseptic/*cerebrospinal fluid
MH  - Mumps/*cerebrospinal fluid
EDAT- 2011/04/20 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1111/j.1442-200X.2010.03215.x [doi]
PST - ppublish
SO  - Pediatr Int. 2011 Apr;53(2):143-6. doi: 10.1111/j.1442-200X.2010.03215.x.