PMID- 21501852
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20161125
IS  - 1532-3072 (Electronic)
IS  - 0040-8166 (Linking)
VI  - 43
IP  - 4
DP  - 2011 Aug
TI  - Effects of 4-nonylphenol on blood cells of the African catfish Clarias gariepinus 
      (Burchell, 1822).
PG  - 223-9
LID - 10.1016/j.tice.2011.03.006 [doi]
AB  - In the present work, the destructive effects of the 4-nonylphenol on one of the 
      most economically important Nile fishes, namely African catfish (Clarias 
      gariepinus) were studied. Apoptosis, erythrocytes alterations, micronucleus test 
      and blood parameters count were used as biological indicators to detect those 
      effects. After exposure to sublethal concentrations of 4-nonylphenol (0, 0.05, 
      0.08 and 0.1mg/l), apoptotic red blood cells with many malformations and 
      micronucleated erythrocytes were recorded. Decrease in the blood parameters such 
      as red blood cells (RBCs), hemoglobin (Hb), package cell volume (PCV), mean 
      corpuscular hemoglobin concentration (MCHC), platelets, white blood cells (WBCs), 
      lymphocytes, basophils, monocytes and increase in mean corpuscular volume (MCV), 
      mean corpuscular hemoglobin (MCH), neutrophils, eosinophils indicated the 
      negative effects of 4-nonylphenol. It was concluded that, the 4-nonylphenol 
      caused genotoxicity in erythrocytes with many malformations in shape and number 
      indicated with other blood parameters.
CI  - Published by Elsevier Ltd.
FAU - Mekkawy, Imam A
AU  - Mekkawy IA
AD  - Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.
FAU - Mahmoud, Usama M
AU  - Mahmoud UM
FAU - Sayed, Alaa El-Din H
AU  - Sayed Ael-D
LA  - eng
PT  - Journal Article
DEP - 20110417
PL  - Scotland
TA  - Tissue Cell
JT  - Tissue & cell
JID - 0214745
RN  - 0 (Phenols)
RN  - 0 (Water Pollutants, Chemical)
RN  - I03GBV4WEL (4-nonylphenol)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Blood Cell Count
MH  - Catfishes/*blood/genetics
MH  - DNA Damage
MH  - Erythrocyte Indices/drug effects
MH  - Erythrocytes/cytology/*drug effects
MH  - Maximum Tolerated Dose
MH  - Phenols/*toxicity
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2011/04/20 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/02/21 00:00 [received]
PHST- 2011/03/21 00:00 [revised]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
AID - S0040-8166(11)00047-4 [pii]
AID - 10.1016/j.tice.2011.03.006 [doi]
PST - ppublish
SO  - Tissue Cell. 2011 Aug;43(4):223-9. doi: 10.1016/j.tice.2011.03.006. Epub 2011 Apr 
      17.