PMID- 21502080
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20211020
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 203
IP  - 10
DP  - 2011 May 15
TI  - Pneumonia in military trainees: a comparison study based on adenovirus serotype 
      14 infection.
PG  - 1388-95
LID - 10.1093/infdis/jir040 [doi]
AB  - BACKGROUND: Adenovirus serotype 14 (Ad-14) recently emerged as a respiratory 
      pathogen in the United States, with studies suggesting higher morbidity and 
      mortality. This study was conducted to determine whether Ad-14 is associated with 
      clinical outcomes in otherwise healthy patients with pneumonia. METHODS: Medical 
      records of military trainees hospitalized with pneumonia during an outbreak of 
      Ad-14 infection were reviewed. Clinical, radiographic, and laboratory parameters 
      were compared on the basis of Ad-14 infection. RESULTS: Two hundred thirty-four 
      trainees received a diagnosis of pneumonia, and 83(35%) were hospitalized. 
      Sixty-one percent of patients with pneumonia were Ad-14 positive; 43% of patients 
      with Ad-14 pneumonia were hospitalized (83% of female patients and 40% of male 
      patients; P = .04), compared with 40% of patients with Ad-14 negative cases. 
      Ad-14 infection was associated with higher admission temperature (38.3 degrees C 
      [interquartile range, (IQR) 37.7, 39.4] vs 37.3 degrees C [IQR (36.7, 38.5)]; P < .01) 
      and lower white blood cell count (8.3 x 1000 cells/muL [IQR, 5.7, 12.4] vs 13 x 
      1000 cells/muL [IQR, 7.5, 12.9]; P = .01), neutrophil count (6.7 x 1000 cells/muL 
      [IQR, 2.8, 9.7] vs 9.7 x 1000 cells/muL [IQR, 5.6, 12.1]; P = .02), lymphocyte 
      count (0.9 x 1000 cells/muL [IQR, 0.8, 1.1] vs 1.3 x 1000 cells/muL [IQR, 1, 1.9]; 
      P = .001), and platelet count (210 x 1000 cells/muL [IQR, 145, 285] vs 261 x 1000 
      cells/muL [IQR, 238, 343]; P < .01). Ad-14 pneumonia was not associated with 
      specific radiographic findings, pneumonia severity score, intensive care unit 
      admission, longer hospitalization, or 30-day mortality. CONCLUSIONS: During an 
      outbreak of Ad-14 infection, Ad-14 infection was not associated with excess 
      overall morbidity or mortality. Ad-14 infection was associated with specific 
      laboratory and clinical parameters and higher hospitalization rates in female 
      trainees. These data provide new insight to the epidemiology of Ad-14 infection.
FAU - Vento, Todd J
AU  - Vento TJ
AD  - Infectious Diseases Service, Department of Medicine, Brooke Army Medical Center, 
      Fort Sam Houston, TX 78234, USA. todd.vento@us.army.mil
FAU - Prakash, Vidhya
AU  - Prakash V
FAU - Murray, Clinton K
AU  - Murray CK
FAU - Brosch, Lorie C
AU  - Brosch LC
FAU - Tchandja, Juste B
AU  - Tchandja JB
FAU - Cogburn, Cynthia
AU  - Cogburn C
FAU - Yun, Heather C
AU  - Yun HC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
MH  - Adenoviridae/*classification
MH  - Adenoviridae Infections/epidemiology/pathology/*virology
MH  - Adolescent
MH  - Disease Outbreaks
MH  - Female
MH  - Humans
MH  - Male
MH  - *Military Personnel
MH  - Pneumonia, Viral/epidemiology/pathology/*virology
MH  - Retrospective Studies
MH  - United States/epidemiology
MH  - Young Adult
PMC - PMC3080896
EDAT- 2011/04/20 06:00
MHDA- 2011/07/01 06:00
PMCR- 2012/05/15
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
PHST- 2012/05/15 00:00 [pmc-release]
AID - jir040 [pii]
AID - 10.1093/infdis/jir040 [doi]
PST - ppublish
SO  - J Infect Dis. 2011 May 15;203(10):1388-95. doi: 10.1093/infdis/jir040.