PMID- 21502241
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20191210
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 127 Suppl 1
DP  - 2011 May
TI  - Tracking vaccine-safety inquiries to detect signals and monitor public concerns.
PG  - S87-91
LID - 10.1542/peds.2010-1722M [doi]
AB  - BACKGROUND: The Centers for Disease Control and Prevention frequently receives 
      inquiries from health care providers, public health officials, and the general 
      public seeking data or guidance on vaccine-safety issues. Past inquiries to 
      public health authorities identified potential problems including viscerotropic 
      illness rarely associated with yellow fever vaccination. OBJECTIVE: To 
      systematically describe vaccine-safety inquiries received at the Centers for 
      Disease Control and Prevention. METHODS: External and internal inquiries were 
      recorded in a database from May 1, 2002 to May 31, 2009. Key variables analyzed 
      included the source of the question, the type of information being sought, and 
      the vaccine type(s) associated with the inquiry. RESULTS: A total of 983 
      vaccine-safety inquiries were answered and analyzed. Health care workers were the 
      source of 43% of the questions, and the general public accounted for 19% of the 
      questions. Nearly half of the requests (49%) concerned information about the 
      Vaccine Adverse Event Reporting System, and nearly one-fourth (21%) were requests 
      from providers for clinical guidance. The most frequent specific topics of 
      inquiry and vaccines involved were neurologic adverse events (AEs) temporally 
      associated with vaccination (17%) and safety of all vaccines or childhood 
      vaccines (20%), respectively. CONCLUSIONS: Questions about rare but potentially 
      serious AEs and general concerns about vaccine safety were encountered relatively 
      frequently. The substantial number of clinically focused inquiries may indicate a 
      need for more provider support tools and resources. Tracking of inquiries can 
      supplement information received through vaccine AE reporting and contribute to an 
      enhanced scientific and communications response to vaccine-safety concerns.
FAU - Miller, Elaine
AU  - Miller E
AD  - Division of Healthcare Quality Promotion, Immunization Safety Office, Centers for 
      Disease Control and Prevention, Mail Stop D-26, 1600 Clifton Rd, Atlanta, GA 
      30333, USA. erm4@cdc.gov
FAU - Batten, Brigid
AU  - Batten B
FAU - Hampton, Lee
AU  - Hampton L
FAU - Campbell, Scott R
AU  - Campbell SR
FAU - Gao, Jinrong
AU  - Gao J
FAU - Iskander, John
AU  - Iskander J
LA  - eng
PT  - Journal Article
DEP - 20110418
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Vaccines)
SB  - IM
MH  - *Adverse Drug Reaction Reporting Systems
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Databases, Factual
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Informatics/*organization & administration
MH  - *Surveys and Questionnaires
MH  - United States
MH  - Vaccines/administration & dosage/*adverse effects
EDAT- 2011/04/20 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - peds.2010-1722M [pii]
AID - 10.1542/peds.2010-1722M [doi]
PST - ppublish
SO  - Pediatrics. 2011 May;127 Suppl 1:S87-91. doi: 10.1542/peds.2010-1722M. Epub 2011 
      Apr 18.