PMID- 21502956
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20220321
IS  - 1476-5551 (Electronic)
IS  - 0887-6924 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Jul
TI  - Continuing high early death rate in acute promyelocytic leukemia: a 
      population-based report from the Swedish Adult Acute Leukemia Registry.
PG  - 1128-34
LID - 10.1038/leu.2011.78 [doi]
AB  - Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based 
      on data from clinical trials, whereas population-based information is scarce. We 
      studied APL patients diagnosed between 1997 and 2006 in the population-based 
      Swedish Adult Acute Leukemia Registry. Of a total of 3897 acute leukemia cases, 
      3205 (82%) had non-APL acute myeloid leukemia (AML) and 105 (2.7%) had APL. The 
      incidence of APL was 0.145 per 100,000 inhabitants per year. The median age at 
      the time of diagnosis was 54 years; 62% were female and 38% male. Among younger 
      APL patients, female sex predominated (89% of patients <40 years). Of the 105 APL 
      patients, 30 (29%) died within 30 days (that is, early death (ED)) (median 4 
      days) and 28 (26%) within 14 days from diagnosis. In all, 41% of the EDs were due 
      to hemorrhage; 35% of ED patients never received all-trans-retinoic acid 
      treatment. ED rates increased with age but more clearly with poor performance 
      status. ED was also associated with high white blood cells, lactate 
      dehydrogenase, creatinine, C-reactive protein and low platelet count. Of non-ED 
      patients, 97% achieved complete remission of which 16% subsequently relapsed. In 
      total, 62% are still alive at 6.4 years median follow-up. We conclude that ED 
      rates remain very high in an unselected APL population.
FAU - Lehmann, S
AU  - Lehmann S
AD  - Hematology Centre, Karolinska University Hospital, Huddinge, Stockholm, Sweden. 
      Soren.Lehmann@ki.se
FAU - Ravn, A
AU  - Ravn A
FAU - Carlsson, L
AU  - Carlsson L
FAU - Antunovic, P
AU  - Antunovic P
FAU - Deneberg, S
AU  - Deneberg S
FAU - Mollgard, L
AU  - Mollgard L
FAU - Derolf, A Rangert
AU  - Derolf AR
FAU - Stockelberg, D
AU  - Stockelberg D
FAU - Tidefelt, U
AU  - Tidefelt U
FAU - Wahlin, A
AU  - Wahlin A
FAU - Wennstrom, L
AU  - Wennstrom L
FAU - Hoglund, M
AU  - Hoglund M
FAU - Juliusson, G
AU  - Juliusson G
LA  - eng
PT  - Journal Article
DEP - 20110419
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Cause of Death
MH  - Female
MH  - Hemorrhage/etiology/mortality
MH  - Humans
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Leukemia, Promyelocytic, Acute/blood/complications/diagnosis/drug 
      therapy/*mortality
MH  - Male
MH  - Middle Aged
MH  - Mortality/trends
MH  - Prognosis
MH  - Registries
MH  - Risk Factors
MH  - Sex Distribution
MH  - Sweden/epidemiology
MH  - Time Factors
MH  - Young Adult
EDAT- 2011/04/20 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - leu201178 [pii]
AID - 10.1038/leu.2011.78 [doi]
PST - ppublish
SO  - Leukemia. 2011 Jul;25(7):1128-34. doi: 10.1038/leu.2011.78. Epub 2011 Apr 19.