PMID- 21503885
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20220330
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 227
IP  - 2
DP  - 2012 Feb
TI  - Functional regulation of HIF-1alpha under normoxia--is there more than 
      post-translational regulation?
PG  - 514-24
LID - 10.1002/jcp.22798 [doi]
AB  - The hypoxia-inducible factor-1 (HIF-1) is an oxygen-regulated transcriptional 
      activator playing a pivotal role in mammalian physiology and disease 
      pathogenesis, e.g., HIF-1 is indispensable in a broad range of developmental 
      stages in different tumors. Its post-translational regulation via PHDs under the 
      influence of hypoxia is widely investigated and accepted. Different non-hypoxic 
      stimuli such as lipopolysaccharides (LPS), thrombin, and angiotensin II (Ang II), 
      have been proven to enhance HIF-1 levels through activation of regulative 
      mechanisms distinct from protein stabilization. Some of these stimuli 
      specifically regulate HIF-1alpha at the transcriptional, post-transcriptional, or 
      translational level, whereas others additionally influence post-translational 
      modifications. Thus, it is difficult for the investigators to discern the impact 
      of the different mechanisms leading to functional HIF-1 protein. Nevertheless, 
      profound knowledge of additional regulatory networks appears to depict new 
      therapeutic opportunities and thus is an interesting and important field for 
      further investigations.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Kuschel, A
AU  - Kuschel A
AD  - Department of Sports Medicine, Rehabilitation and Disease Prevention, 
      Johannes-Gutenberg-University Mainz, Germany.
FAU - Simon, P
AU  - Simon P
FAU - Tug, S
AU  - Tug S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation/*physiology
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism
MH  - Mammals/*physiology
MH  - Oxygen/*metabolism
EDAT- 2011/04/20 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
AID - 10.1002/jcp.22798 [doi]
PST - ppublish
SO  - J Cell Physiol. 2012 Feb;227(2):514-24. doi: 10.1002/jcp.22798.