PMID- 21504434
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20131121
IS  - 1600-0536 (Electronic)
IS  - 0105-1873 (Linking)
VI  - 64
IP  - 6
DP  - 2011 Jun
TI  - Clinical and experimental studies of octocrylene's allergenic potency.
PG  - 343-52
LID - 10.1111/j.1600-0536.2011.01899.x [doi]
AB  - BACKGROUND: Reports of positive patch test and photopatch test reactions to the 
      chemical ultraviolet filter octocrylene have increased during the last decade. 
      Little is known about the reason for octocrylene's allergenic activity. 
      OBJECTIVES: To present and discuss the results of patch tests and photopatch 
      tests with octocrylene, and to investigate the possible cause of its allergenic 
      properties. METHODS: Results of patch tests and photopatch tests with octocrylene 
      in patients with adverse skin reactions to sunscreen products and/or ketoprofen 
      were collected. The allergenic potency of octocrylene was investigated in the 
      murine local lymph node assay (LLNA). Chemical reactivity assays were used to 
      mimic octocrylene's interaction with biomolecules. RESULTS: We report 23 cases of 
      positive test reactions to octocrylene (5 patch test and 18 photopatch). Notably, 
      many of these patients also had positive photopatch test reactions to ketoprofen 
      and benzophenone-3. Octocrylene was shown to be a moderate sensitizer in the 
      LLNA, and it reacted with amines such as lysine, but not with thiols such as 
      cysteine. CONCLUSIONS: The clinical studies show that octocrylene is both a 
      photocontact allergen and a contact allergen. Octocrylene's ability to cause 
      contact allergy is probably attributable to its reactivity towards lysine. To be 
      able to understand why octocrylene causes photocontact allergy, further studies 
      are needed.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Karlsson, Isabella
AU  - Karlsson I
AD  - Dermatochemistry and Skin Allergy, Department of Chemistry, University of 
      Gothenburg, SE-412 96, Gothenburg, Sweden.
FAU - Vanden Broecke, Katrien
AU  - Vanden Broecke K
FAU - Martensson, Jerker
AU  - Martensson J
FAU - Goossens, An
AU  - Goossens A
FAU - Borje, Anna
AU  - Borje A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110419
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Acrylates)
RN  - 0 (Benzophenones)
RN  - 0 (Sunscreening Agents)
RN  - 5A68WGF6WM (octocrylene)
RN  - 90Y4QC304K (Ketoprofen)
RN  - 95OOS7VE0Y (oxybenzone)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Acrylates/*adverse effects/metabolism
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Benzophenones/adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Allergic Contact/*etiology
MH  - Dermatitis, Photoallergic/etiology
MH  - Female
MH  - Humans
MH  - Ketoprofen/adverse effects
MH  - Local Lymph Node Assay
MH  - Lysine/metabolism
MH  - Male
MH  - Mice
MH  - Middle Aged
MH  - Patch Tests/methods
MH  - Skin/metabolism
MH  - Sunscreening Agents/*adverse effects
MH  - Young Adult
EDAT- 2011/04/21 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/04/21 06:00
PHST- 2011/04/21 06:00 [entrez]
PHST- 2011/04/21 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 10.1111/j.1600-0536.2011.01899.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 2011 Jun;64(6):343-52. doi: 10.1111/j.1600-0536.2011.01899.x. 
      Epub 2011 Apr 19.