PMID- 21507492
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20220321
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 235
IP  - 1-2
DP  - 2011 Jun
TI  - Vitamin D-related gene expression profiles in immune cells of patients with 
      relapsing remitting multiple sclerosis.
PG  - 91-7
LID - 10.1016/j.jneuroim.2011.03.012 [doi]
AB  - An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting 
      multiple sclerosis (RRMS) patients may increase their vulnerability for a poor 
      vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC 
      and CD4+ T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and 
      CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, 
      more VDR expression in PBMC correlated with less circulating IFN-gamma+ CD4+ T-cells. 
      Our results suggest that vit-D processing by immune cells is not impaired in 
      RRMS, and is potentially relevant for the composition of the peripheral CD4+ 
      T-cell compartment.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Smolders, Joost
AU  - Smolders J
AD  - School for Mental Health and Neuroscience, Maastricht University Medical Center, 
      PO Box 616, 6200 MD Maastricht, The Netherlands. smolders@gmail.com
FAU - Thewissen, Marielle
AU  - Thewissen M
FAU - Theunissen, Ruud
AU  - Theunissen R
FAU - Peelen, Evelyn
AU  - Peelen E
FAU - Knippenberg, Stephanie
AU  - Knippenberg S
FAU - Menheere, Paul
AU  - Menheere P
FAU - Cohen Tervaert, Jan Willem
AU  - Cohen Tervaert JW
FAU - Hupperts, Raymond
AU  - Hupperts R
FAU - Damoiseaux, Jan
AU  - Damoiseaux J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110420
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Receptors, Calcitriol)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - CD4-Positive T-Lymphocytes/immunology/*pathology
MH  - Cohort Studies
MH  - Female
MH  - Gene Expression Profiling/*methods
MH  - Humans
MH  - Leukocytes, Mononuclear/immunology/*pathology
MH  - Male
MH  - Multiple Sclerosis, Relapsing-Remitting/*genetics/*immunology/pathology
MH  - Receptors, Calcitriol/*biosynthesis/genetics
MH  - Vitamin D/*biosynthesis/genetics
EDAT- 2011/04/22 06:00
MHDA- 2011/08/09 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/02/24 00:00 [received]
PHST- 2011/03/25 00:00 [revised]
PHST- 2011/03/28 00:00 [accepted]
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
AID - S0165-5728(11)00096-8 [pii]
AID - 10.1016/j.jneuroim.2011.03.012 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2011 Jun;235(1-2):91-7. doi: 10.1016/j.jneuroim.2011.03.012. Epub 
      2011 Apr 20.