PMID- 21508136
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20240323
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 96
IP  - 6
DP  - 2011 Jun
TI  - The high serum monocyte chemoattractant protein-1 in obesity is influenced by 
      high parathyroid hormone and not adiposity.
PG  - 1852-8
LID - 10.1210/jc.2010-2781 [doi]
AB  - CONTEXT: Chronic high levels of PTH may be associated with up-regulation of 
      proteases and cytokines. Monocyte chemoattractant protein-1 (MCP-1) is an 
      inflammatory cytokine, produced predominantly by macrophages and endothelial 
      cells, and is expressed in adipose tissue. More recently it has been shown that 
      PTH administration increases MCP-1 expression in osteoblasts. OBJECTIVES: Because 
      both PTH and MCP-1 levels are higher in obesity, the goal was to determine 
      whether the high MCP-1 occurs only in the presence of high serum PTH and is 
      independent of adiposity and examine its relationship with bone mineral density 
      (BMD) and turnover. DESIGN, SETTING, AND PARTICIPANTS: In this case-control 
      clinical design, 111 eligible women were categorized into four groups: leaner 
      women [body mass index (BMI) 23 +/- 2 kg/m(2)] with normal or higher PTH and obese 
      (BMI 44 +/- 7 kg/m(2)) with normal or higher PTH. RESULTS: Serum MCP-1 levels were 
      higher (P < 0.01) in the high (PTH = 74.9 +/- 27.0 pg/ml, MCP-1 = 421.5 +/- 157.0 
      pg/ml) compared with normal PTH (PTH = 32.5 +/- 10.4 pg/ml, MCP-1 = 322.5 +/- 97.8 
      pg/ml) group, independent of BMI. C-reactive protein and adiponectin were 
      influenced only by BMI and not PTH. MCP-1 was positively associated with 
      osteocalcin and propeptide of type 1 collagen in the leaner (r > 0.3, P < 0.05) 
      but not the obese women and was not associated with BMD in either group. 
      CONCLUSIONS: Together these data suggest that MCP-1 is higher only in the 
      presence of increased PTH and that adiposity alone cannot explain the higher 
      MCP-1 levels in obesity.
FAU - Sukumar, D
AU  - Sukumar D
AD  - Department of Nutritional Sciences, Rutgers University, 96 Lipman Drive, New 
      Brunswick, New Jersey 08901-8525, USA.
FAU - Partridge, N C
AU  - Partridge NC
FAU - Wang, X
AU  - Wang X
FAU - Shapses, S A
AU  - Shapses SA
LA  - eng
GR  - R01 AG012161/AG/NIA NIH HHS/United States
GR  - R01 DK047420/DK/NIDDK NIH HHS/United States
GR  - AG12161/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110420
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Chemokine CCL2)
RN  - 0 (Parathyroid Hormone)
SB  - IM
MH  - Adiposity/*physiology
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Bone Density/physiology
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Obesity/*blood
MH  - Parathyroid Hormone/*blood
MH  - Regression Analysis
PMC - PMC3206398
EDAT- 2011/04/22 06:00
MHDA- 2011/08/06 06:00
PMCR- 2012/06/01
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - jc.2010-2781 [pii]
AID - 10-2781 [pii]
AID - 10.1210/jc.2010-2781 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2011 Jun;96(6):1852-8. doi: 10.1210/jc.2010-2781. Epub 
      2011 Apr 20.