PMID- 21511355
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20111014
IS  - 1872-8332 (Electronic)
IS  - 0169-5002 (Linking)
VI  - 74
IP  - 2
DP  - 2011 Nov
TI  - Coexisting pulmonary nodules in operable lung cancer: prevalence and probability 
      of malignancy.
PG  - 233-8
LID - 10.1016/j.lungcan.2011.03.012 [doi]
AB  - INTRODUCTION: Coexistence of pulmonary nodules in operable non small cell lung 
      cancer (NSCLC) may influence the therapeutic indication. The aim of this study 
      was to evaluate prospectively the prevalence and the probability of malignancy of 
      pulmonary nodules in operable lung cancer. METHODS: From a prospective database, 
      all surgically treated patients diagnosed with NSCLC from 1998 to 2003 were 
      retrospectively reviewed. Patients presenting pulmonary nodule(s) were 
      identified. RESULTS: Two hundred thirty nine patients had a complete resection 
      for a NSCLC and 56 patients (24%) presented altogether 88 nodules on thoracic CT. 
      Twenty-four of these nodules (27%) were malignant, 28 (32%) benign and 36 (41%) 
      of undetermined nature. Five factors associated with nodule's malignancy were 
      identified: tumour histology (non-squamous (non-SCC) 44% vs. SCC 7%, p=0.001), 
      localization of the nodules in an upper lobe (vs. other lobe, p=0.004), co 
      localization in the same lobe as the NSCLC (vs. another lobe, p=0.03), nodule 
      size (p=0.05) and shape (speculated vs. non spiculated, p=0.02). From these 
      factors, a probability score was assessed with a malignancy rate in SCC of 0% in 
      nodules presenting </= 1 feature, 33% with 2 features and 100% with >/= 3 features 
      and in non-SCC of 40% with 1 feature, 82% with 2 features and 100% with 3 >/= 
      features. CONCLUSION: Diagnosis of satellite nodules associated with early stage 
      NSCLC is common. We developed a predictive score to estimate the probability of 
      malignancy which may be a precious aid in the management of pulmonary nodules 
      associated to a NSCLC.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Ruppert, A M
AU  - Ruppert AM
AD  - Service de Pneumologie, Hopital Tenon APHP and Universite Paris IV, France. 
      anne-marie.ruppert@tnn.aphp.fr
FAU - Lerolle, U
AU  - Lerolle U
FAU - Carette, M F
AU  - Carette MF
FAU - Lavole, A
AU  - Lavole A
FAU - Khalil, A
AU  - Khalil A
FAU - Bazelly, B
AU  - Bazelly B
FAU - Antoine, M
AU  - Antoine M
FAU - Cadranel, J
AU  - Cadranel J
FAU - Milleron, B
AU  - Milleron B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110420
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*diagnosis/epidemiology/pathology
MH  - Early Detection of Cancer
MH  - Female
MH  - Humans
MH  - Lung Diseases/*diagnosis/epidemiology/pathology
MH  - Lung Neoplasms/*diagnosis/epidemiology/pathology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - Solitary Pulmonary Nodule/*diagnosis/epidemiology/pathology
MH  - Tomography, X-Ray Computed
EDAT- 2011/04/23 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/04/23 06:00
PHST- 2010/12/17 00:00 [received]
PHST- 2011/03/07 00:00 [revised]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - S0169-5002(11)00173-5 [pii]
AID - 10.1016/j.lungcan.2011.03.012 [doi]
PST - ppublish
SO  - Lung Cancer. 2011 Nov;74(2):233-8. doi: 10.1016/j.lungcan.2011.03.012. Epub 2011 
      Apr 20.