PMID- 21511871
OWN - NLM
STAT- MEDLINE
DCOM- 20110706
LR  - 20220318
IS  - 1549-5477 (Electronic)
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 25
IP  - 10
DP  - 2011 May 15
TI  - Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in 
      response to blue light.
PG  - 1029-34
LID - 10.1101/gad.2025011 [doi]
AB  - Plant photoreceptors mediate light suppression of the E3 ubiquitin ligase COP1 
      (CONSTITUTIVE PHOTOMORPHOGENIC 1) to affect gene expression and 
      photomorphogenesis. However, how photoreceptors mediate light regulation of COP1 
      activity remains unknown. We report here that Arabidopsis blue-light receptor 
      cryptochrome 1 (CRY1) undergoes blue-light-dependent interaction with the 
      COP1-interacting protein SPA1 (SUPPRESSOR OF PHYTOCHROME A). We further show that 
      the CRY1-SPA1 interaction suppresses the SPA1-COP1 interaction and COP1-dependent 
      degradation of the transcription factor HY5. These results are consistent with a 
      hypothesis that photoexcited CRY1 interacts with SPA1 to modulate COP1 activity 
      and plant development.
FAU - Liu, Bin
AU  - Liu B
AD  - Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 
      China.
FAU - Zuo, Zecheng
AU  - Zuo Z
FAU - Liu, Hongtao
AU  - Liu H
FAU - Liu, Xuanming
AU  - Liu X
FAU - Lin, Chentao
AU  - Lin C
LA  - eng
GR  - R01 GM056265/GM/NIGMS NIH HHS/United States
GR  - R29 GM056265/GM/NIGMS NIH HHS/United States
GR  - GM56265/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110421
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (CRY1 protein, Arabidopsis)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cryptochromes)
RN  - 0 (HY5 protein, Arabidopsis)
RN  - 0 (Nuclear Proteins)
RN  - 0 (SPA1 protein, Arabidopsis)
RN  - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
CIN - Genes Dev. 2011 May 15;25(10):1004-9. PMID: 21576261
MH  - Arabidopsis/enzymology/genetics/metabolism/*physiology
MH  - Arabidopsis Proteins/*metabolism
MH  - Basic-Leucine Zipper Transcription Factors/metabolism
MH  - Cell Cycle Proteins/*metabolism
MH  - Cryptochromes/*metabolism
MH  - *Gene Expression Regulation, Plant
MH  - *Light
MH  - Nuclear Proteins/metabolism
MH  - Plants, Genetically Modified/metabolism
MH  - Seedlings/growth & development/metabolism
MH  - Ubiquitin-Protein Ligases/*metabolism
PMC - PMC3093118
EDAT- 2011/04/23 06:00
MHDA- 2011/07/08 06:00
PMCR- 2011/11/15
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/07/08 06:00 [medline]
PHST- 2011/11/15 00:00 [pmc-release]
AID - gad.2025011 [pii]
AID - 10.1101/gad.2025011 [doi]
PST - ppublish
SO  - Genes Dev. 2011 May 15;25(10):1029-34. doi: 10.1101/gad.2025011. Epub 2011 Apr 
      21.