PMID- 21512277
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20190608
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Linking)
VI  - 18
IP  - 7
DP  - 2011
TI  - Adiponectin multimeric forms but not total adiponectin levels are associated with 
      myocardial infarction in non-diabetic men.
PG  - 616-27
AB  - AIM: Multimer complex formation of adiponectin is recognized as an important 
      mechanism modulating the biological functions of this adipokine, but the role of 
      adiponectin isoforms in myocardial infarction (MI) is still unclear. METHODS: We 
      quantified total adiponectin (TOTAL), high, middle, and low molecular weight 
      adiponectin multimers (HMW, MMW, LMW) in a study of non-diabetic obese (BMI >/= 30 
      kg/m(2)) and normal-weight (BMI </= 25 kg/m(2)) male subjects with MI and healthy 
      controls (n=180). Subsequently, we designed a prospective nested-case-control 
      study to investigate the association of the adiponectin multimers with fatal and 
      non-fatal MI in n=1236 initially healthy non-diabetic men. RESULTS: Obesity was 
      significantly related to lower levels of TOTAL, HMW, MMW, and LMW in subjects 
      with and without MI (p < 0.01, each). In contrast, MI was strongly related to 
      MMW/TOTAL (p < 0.0001), inversely to HMW/TOTAL (p < 0.0001), but not TOTAL or LMW 
      levels. In particular, the median MMW/HMW ratios were markedly different in men 
      with MI (1.71, interquartile range (1.08-2.40)) and without (0.72 (0.49-1.08), p 
      < 0.0001). In the prospective study, 56 incident fatal and non-fatal MI events 
      occured. The MMW/HMW ratio was associated with fatal and non-fatal MI up to 5 
      years before the event. The beta-estimates for the relationship between MMW/HMW and 
      incident MI decreased with increasing time to the event. CONCLUSIONS: Whereas 
      total adiponectin and all isoforms are related to obesity, total adiponectin and 
      LMW levels are not associated with MI in non-diabetic men. In contrast, the 
      MMW/HMW-ratio correlated with incident MI up to 5 years before the event. These 
      data imply that measurement of adiponectin multimers adds significant value in 
      assessing cardiovascular risk compared to total adiponectin alone.
FAU - Baessler, Andrea
AU  - Baessler A
AD  - Clinic for Internal Medicine II, University of Regensburg, Germany.
FAU - Schlossbauer, Susanne
AU  - Schlossbauer S
FAU - Stark, Klaus
AU  - Stark K
FAU - Strack, Christina
AU  - Strack C
FAU - Riegger, Gunter
AU  - Riegger G
FAU - Schunkert, Heribert
AU  - Schunkert H
FAU - Hengstenberg, Christian
AU  - Hengstenberg C
FAU - Fischer, Marcus
AU  - Fischer M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110421
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Adiponectin/blood/*chemistry
MH  - Adult
MH  - Biomarkers/metabolism
MH  - Cardiovascular Diseases/complications
MH  - Case-Control Studies
MH  - Humans
MH  - Inflammation
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/diagnosis
MH  - Obesity/blood
MH  - Prospective Studies
MH  - Protein Isoforms
MH  - Regression Analysis
MH  - Risk Factors
EDAT- 2011/04/23 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - JST.JSTAGE/jat/8359 [pii]
AID - 10.5551/jat.8359 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2011;18(7):616-27. doi: 10.5551/jat.8359. Epub 2011 Apr 21.