PMID- 21513566
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20240320
IS  - 1758-3284 (Electronic)
IS  - 1758-3284 (Linking)
VI  - 3
DP  - 2011 Apr 24
TI  - Mammalian target of rapamycin and head and neck squamous cell carcinoma.
PG  - 22
LID - 10.1186/1758-3284-3-22 [doi]
AB  - Head and neck squamous cell carcinoma (HNSCC), a significant cause of cancer 
      deaths worldwide, has multiple stepwise malignant evolutions. Mammalian target of 
      rapamycin (mTOR) plays a critical role in tumor development, invasion, metastasis 
      and angiogenesis that impact local recurrence and survival. mTOR can also act as 
      a biomarker for personalized adjuvant therapy. In in vivo and in vitro studies, 
      mTOR inhibitor suppresses tumor growth and sensitizes HNSCC to radiation, 
      cytotoxic agents and epidermoid growth factor receptor inhibitors. We have 
      reviewed the pathogenesis of HNSCC, mTOR pathway, mTOR inhibitor and the role of 
      mTOR in HNSCC.
FAU - Liao, Yu-Min
AU  - Liao YM
AD  - Department of Internal Medicine, China Medical University Hospital, Taichung, 
      Taiwan.
FAU - Kim, Charles
AU  - Kim C
FAU - Yen, Yun
AU  - Yen Y
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110424
PL  - England
TA  - Head Neck Oncol
JT  - Head & neck oncology
JID - 101479704
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/therapeutic use
MH  - Carcinoma/drug therapy/*etiology/genetics
MH  - Carcinoma, Squamous Cell
MH  - Head and Neck Neoplasms/drug therapy/*etiology/genetics
MH  - Humans
MH  - Models, Biological
MH  - Neoplasms, Squamous Cell/drug therapy/*etiology/genetics
MH  - Protein Kinase Inhibitors/therapeutic use
MH  - Signal Transduction/drug effects/genetics/physiology
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - TOR Serine-Threonine Kinases/antagonists & inhibitors/genetics/*physiology
PMC - PMC3108931
EDAT- 2011/04/26 06:00
MHDA- 2011/09/29 06:00
PMCR- 2011/04/24
CRDT- 2011/04/26 06:00
PHST- 2011/03/06 00:00 [received]
PHST- 2011/04/24 00:00 [accepted]
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PHST- 2011/04/24 00:00 [pmc-release]
AID - 1758-3284-3-22 [pii]
AID - 10.1186/1758-3284-3-22 [doi]
PST - epublish
SO  - Head Neck Oncol. 2011 Apr 24;3:22. doi: 10.1186/1758-3284-3-22.