PMID- 21513754
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20110613
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 7
DP  - 2011 Jul
TI  - High-resolution human leukocyte antigen allele and haplotype frequencies of the 
      Polish population based on 20,653 stem cell donors.
PG  - 558-65
LID - 10.1016/j.humimm.2011.03.010 [doi]
AB  - We present high-resolution allele and haplotype frequency (HF) estimations of the 
      Polish population based on more than 20,000 registered stem cell donors. 
      Sequencing-based donor human leukocyte antigen (HLA) typing led to unambiguous 
      typing results in most cases (between 94.3% for HLA-DRB1 and 96.9% for HLA-B). HF 
      estimations were carried out with a new, validated implementation of the 
      expectation-maximization algorithm that allowed processing of data with 
      ambiguities. Our results confirm several earlier results, for example, the 
      relative commonness of the haplotype A*25:01 g, B*18:01 g, C*12:03, DRB1*04:01 in 
      the Polish population. Because of the large sample size, we were able to obtain 
      results of unprecedented accuracy. The estimated population-specific HFs were 
      then used to analyze questions of strategic donor registry planning. Simulated 
      matching probabilities by donor file size suggest that there is a need for 
      intense donor recruitment efforts in Poland despite the large German donor 
      registry and the genetic relatedness of both populations. Based on the current 
      German registry size of approximately 4 million donors, the recruitment of 
      100,000 Polish donors would produce a stronger increase in matching probabilities 
      for Polish patients than the recruitment of 3.3 million additional German donors.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Schmidt, Alexander H
AU  - Schmidt AH
AD  - DKMS German Bone Marrow Donor Center, Tubingen, Germany. schmidt@dkms.de
FAU - Solloch, Ute V
AU  - Solloch UV
FAU - Pingel, Julia
AU  - Pingel J
FAU - Baier, Daniel
AU  - Baier D
FAU - Bohme, Irina
AU  - Bohme I
FAU - Dubicka, Kinga
AU  - Dubicka K
FAU - Schumacher, Stephan
AU  - Schumacher S
FAU - Rutt, Claudia
AU  - Rutt C
FAU - Skotnicki, Aleksander B
AU  - Skotnicki AB
FAU - Wachowiak, Jacek
AU  - Wachowiak J
FAU - Ehninger, Gerhard
AU  - Ehninger G
LA  - eng
PT  - Journal Article
DEP - 20110408
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Alleles
MH  - Gene Frequency/*genetics
MH  - HLA Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Poland
MH  - Registries
MH  - Reproducibility of Results
MH  - *Stem Cells
MH  - *Tissue Donors
EDAT- 2011/04/26 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/04/26 06:00
PHST- 2010/12/29 00:00 [received]
PHST- 2011/03/11 00:00 [revised]
PHST- 2011/03/31 00:00 [accepted]
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
AID - S0198-8859(11)00063-2 [pii]
AID - 10.1016/j.humimm.2011.03.010 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Jul;72(7):558-65. doi: 10.1016/j.humimm.2011.03.010. Epub 2011 
      Apr 8.