PMID- 21515307
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20131121
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 223
IP  - 1
DP  - 2011 Sep 30
TI  - Sporadic dementia of Alzheimer's type induced by streptozotocin promotes 
      anxiogenic behavior in mice.
PG  - 1-6
LID - 10.1016/j.bbr.2011.04.014 [doi]
AB  - Alzheimer disease, a form of dementia in which loss of memory is the first and 
      the most characteristic symptom, is frequently accompanied by affective symptoms. 
      Intracerebroventricular (i.c.v.) injection of streptozotocin (STZ) to rodents has 
      been reported as an appropriate model for sporadic dementia of Alzheimer's type 
      (SDAT), characterized by a progressive impairment of memory. However, very little 
      or nothing is known about non-cognitive behavioral effects (e.g. anxiety-like 
      behavior) in the STZ model. In this context, the hypothesis to be tested in this 
      study is if i.c.v. injection of STZ (0.1mg/site, 4 mul) induces anxiety-like 
      behavior in mice. The findings of the present study indicate that i.c.v. 
      injection of STZ in mice resulted in an anxiogenic behavior. Mice spent less time 
      and decreased the number of entries in the open arms in the elevated plus-maze 
      task. The latency to the first entry in the dark side in the light-dark box task 
      was reduced by STZ. No difference was found in anxiety-like behavior between 
      early and late time (i.e., at 7 and 21 days after infusion, respectively). These 
      results indicate that i.c.v. STZ injection caused an anxiogenic behavior in mice.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Pinton, Simone
AU  - Pinton S
AD  - Laboratorio de Sintese, Reatividade e Avaliacao Farmacologica e Toxicologica de 
      Organocalcogenios. Centro de Ciencias Naturais e Exatas, Universidade Federal de 
      Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
FAU - da Rocha, Juliana Trevisan
AU  - da Rocha JT
FAU - Gai, Bibiana Mozzaquatro
AU  - Gai BM
FAU - Nogueira, Cristina Wayne
AU  - Nogueira CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110415
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Blood Glucose)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Alzheimer Disease/blood/chemically induced/*psychology
MH  - Animals
MH  - Anxiety/blood/chemically induced/*psychology
MH  - Avoidance Learning/drug effects
MH  - Blood Glucose/metabolism
MH  - Choice Behavior/drug effects
MH  - Disease Models, Animal
MH  - Injections, Intraventricular
MH  - Male
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Motor Activity/drug effects
MH  - Streptozocin
MH  - Time Factors
EDAT- 2011/04/26 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/04/26 06:00
PHST- 2010/12/10 00:00 [received]
PHST- 2011/04/02 00:00 [revised]
PHST- 2011/04/10 00:00 [accepted]
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
AID - S0166-4328(11)00302-0 [pii]
AID - 10.1016/j.bbr.2011.04.014 [doi]
PST - ppublish
SO  - Behav Brain Res. 2011 Sep 30;223(1):1-6. doi: 10.1016/j.bbr.2011.04.014. Epub 
      2011 Apr 15.